Microglial Cell Line (IMG)

Immortalized microglial cell line (IMG) isolated from the brains of adult mice.


  • Express the markers F4/80 and CD11b but not the neuronal marker NeuN or the astrocyte marker GFAP
  • Display a robust response (M1/M2 polarization) to inflammatory signals and can therefore be used to examine mechanisms of drug action and drug efficacy in regards to M1/M2 polarization
  • Can be induced to pro- or anti-inflammatory microglial phenotypes
  • Able to phagocytose foreign particles and misfolded proteins such as amyloid-beta peptide

Microglia cells share functional similarities with macrophages, and are thought to act as the primary immune cells of the central nervous system (CNS). They monitor their microenviornment and become activated upon detection of abnormal and/or offensive signals. Activated microglia have been found in inflammatory conditions such as brain/spinal cord injury, ischemic strokes, infections and neurodegenerative diseases. Recent findings indicate that microglia are also involved in learning and memory by regulating synaptic plasticity.

From the laboratory of Chih-Hao Lee, PhD, Harvard University.

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Microglial Cell Line (IMG)
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Product Type: Cell Line
Name: Immortalized Microglial Cell (IMG)
Cell Type: Immortalized microglial cell
Accession ID: CVCL_HC49
Morphology: Ramified/Amoeboid
Source: Brain
Organism: Mouse (8-wk-old C57BL/6J)
Biosafety Level: BSL2
Growth Conditions: DMEM with 4.5g/L glucose with glutamate, 10% FBS, 1% Penicillin/Streptomycin
Cryopreservation: Growth Medium + 10% DMSO
Storage: Liquid nitrogen
Shipped: Dry ice

From the laboratory of Chih-Hao Lee, PhD, Harvard University.
  1. McCarthy RC, Lu DY, Alkhateeb A, Gardeck AM, Lee CH, Wessling-Resnick M. Characterization of a novel adult murine immortalized microglial cell line and its activation by amyloid-beta. J Neuroinflammation. 2016 Jan 27;13(1):21. doi: 10.1186/s12974-016-0484-z. PubMed PMID: 26819091.
  2. Castro-Sánchez S, García-Yagüe ÁJ, Kügler S, Lastres-Becker I. CX3CR1-deficient microglia shows impaired signalling of the transcription factor NRF2: Implications in tauopathies. Redox Biol. 2019 Apr;22:101118. View Article
  3. Galán-Ganga M, García-Yagüe ÁJ, Lastres-Becker I. Role of MSK1 in the Induction of NF-κB by the Chemokine CX3CL1 in Microglial Cells. Cell Mol Neurobiol. 2019 Apr;39(3):331-340. View Article
  4. Tom S, Rane A, Katewa AS, Chamoli M, Matsumoto RR, Andersen JK, Chinta SJ. Gedunin Inhibits Oligomeric Aβ(1-42)-Induced Microglia Activation Via Modulation of Nrf2-NF-κB Signaling. Mol Neurobiol. 2019 May 24. View Article

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