Anti-Epithelial Cell Adhesion Molecule (EpCAM) [GA733] Antibody
![Anti-Epithelial Cell Adhesion Molecule (EpCAM) [GA733] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1177_2001202001263711760.jpg "Anti-Epithelial Cell Adhesion Molecule (EpCAM) [GA733] Antibody")
This mouse IgG monoclonal antibody was generated against human cancer cells and recognizes human epithelial cell adhesion molecule (EpCAM).
Highlights:
- Specific for human EpCAM
- Suitable for Western Blot applications
EpCAM encodes a carcinoma-associated antigen and is a type I membrane protein. EpCAM is expressed on most normal epithelial cells and carcinomas and functions as a cell adhesion molecule which does not require Calcium. Epcam may act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. It also plays a role in embryonic stem cells proliferation and differentiation. In clinical research, EpCAM is being considered as a target for immunotherapy treatment of carcinomas.
From the laboratory of Meenhard Herlyn, DVM, DSc, The Wistar Institute.
Part of The Investigator's Annexe program.
This mouse IgG monoclonal antibody was generated against human cancer cells and recognizes human epithelial cell adhesion molecule (EpCAM).
Highlights:
- Specific for human EpCAM
- Suitable for Western Blot applications
EpCAM encodes a carcinoma-associated antigen and is a type I membrane protein. EpCAM is expressed on most normal epithelial cells and carcinomas and functions as a cell adhesion molecule which does not require Calcium. Epcam may act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. It also plays a role in embryonic stem cells proliferation and differentiation. In clinical research, EpCAM is being considered as a target for immunotherapy treatment of carcinomas.
From the laboratory of Meenhard Herlyn, DVM, DSc, The Wistar Institute.
Part of The Investigator's Annexe program.
| Product Type: | Antibody |
| Alternative Name(s): | Adenocarcinoma-associated antigen,Cell surface glycoprotein Trop-1,Epithelial cell surface antigen,Epithelial glycoprotein,EGP,Epithelial glycoprotein 314,EGP314,hEGP314 KS 1/4 antigen,KSA,Major gastrointestinal tumor-associated protein GA733-2,Tumor-associated calcium signal transducer 1 |
| Antigen: | EpCAM |
| Accession ID: | P16422 |
| Molecular Weight: | 35 kDa |
| Isotype: | IgG |
| Clonality: | Monoclonal |
| Clone Name: | GA733 |
| Reactivity: | Human |
| Immunogen: | Human cancer cells, recognizes EpCAM |
| Species Immunized: | Mouse |
| Purification Method: | Protein G |
| Buffer: | PBS, 0.05% (w/v) Sodium Azide |
| Tested Applications: | WB (1:1000) |
| Storage: | -80C |
| Shipped: | Dry ice |
- Herlyn D, Herlyn M, Ross AH, Ernst C, Atkinson B, Koprowski H. Efficient selection of human tumor growth-inhibiting monoclonal antibodies. J ImmunolMethods. 1984 Oct 12;73(1):157-67.
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