This mouse IgG monoclonal antibody was generated against human cancer cells and recognizes human epithelial cell adhesion molecule (EpCAM).
EpCAM encodes a carcinoma-associated antigen and is a type I membrane protein. EpCAM is expressed on most normal epithelial cells and carcinomas and functions as a cell adhesion molecule which does not require Calcium. Epcam may act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. It also plays a role in embryonic stem cells proliferation and differentiation. In clinical research, EpCAM is being considered as a target for immunotherapy treatment of carcinomas.
From the laboratory of Meenhard Herlyn, DVM, DSc, The Wistar Institute.
Part of The Investigator's Annexe program.
|Alternative Name(s):||Adenocarcinoma-associated antigen,Cell surface glycoprotein Trop-1,Epithelial cell surface antigen,Epithelial glycoprotein,EGP,Epithelial glycoprotein 314,EGP314,hEGP314 KS 1/4 antigen,KSA,Major gastrointestinal tumor-associated protein GA733-2,Tumor-associated calcium signal transducer 1|
|Accession ID:||HGNC: 11529 Ensembl: ENSG00000119888 Entrez Gene: 4072 OMIM: 185535 UniProtKB: P16422|
|Molecular Weight:||35 kDa|
|Immunogen:||Human cancer cells, recognizes EpCAM|
|Purification Method:||Protein G|
|Buffer:||PBS, 0.05% (w/v) Sodium Azide|
|Tested Applications:||WB (1:1000)|
If you publish research with this product, please let us know so we can cite your paper.