Anti-Epithelial Cell Adhesion Molecule (EpCAM) [GA733] Antibody

This mouse IgG monoclonal antibody was generated against human cancer cells and recognizes human epithelial cell adhesion molecule (EpCAM).

Highlights:

  • Specific for human EpCAM
  • Suitable for Western Blot applications

EpCAM encodes a carcinoma-associated antigen and is a type I membrane protein. EpCAM is expressed on most normal epithelial cells and carcinomas and functions as a cell adhesion molecule which does not require Calcium. Epcam may act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. It also plays a role in embryonic stem cells proliferation and differentiation. In clinical research, EpCAM is being considered as a target for immunotherapy treatment of carcinomas.

From the laboratory of Meenhard Herlyn, DVM, DSc, The Wistar Institute.

The Investigator's Annexe Part of The Investigator's Annexe program.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
EWI021
Anti-Epithelial Cell Adhesion Molecule (EpCAM) [GA733] Antibody
100ug Currently Unavailable
Regular Price:$321.00
On Sale:
Specifications

Product Type: Antibody
Alternative Name(s): Adenocarcinoma-associated antigen,Cell surface glycoprotein Trop-1,Epithelial cell surface antigen,Epithelial glycoprotein,EGP,Epithelial glycoprotein 314,EGP314,hEGP314 KS 1/4 antigen,KSA,Major gastrointestinal tumor-associated protein GA733-2,Tumor-associated calcium signal transducer 1
Antigen: EpCAM
Accession ID: HGNC: 11529 Ensembl: ENSG00000119888 Entrez Gene: 4072 OMIM: 185535 UniProtKB: P16422
Molecular Weight: 35 kDa
Isotype: IgG
Clonality: Monoclonal
Clone Name: GA733
Reactivity: Human
Immunogen: Human cancer cells, recognizes EpCAM
Species Immunized: Mouse
Purification Method: Protein G
Buffer: PBS, 0.05% (w/v) Sodium Azide
Tested Applications: WB (1:1000)
Storage: -80C
Shipped: Dry ice

Provider
From the laboratory of Meenhard Herlyn, DVM, DSc, The Wistar Institute.
References
  1. Herlyn D, Herlyn M, Ross AH, Ernst C, Atkinson B, Koprowski H. Efficient selection of human tumor growth-inhibiting monoclonal antibodies. J ImmunolMethods. 1984 Oct 12;73(1):157-67.

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