Alkynyl 4-hydroxy-2-nonenal (aHNE)
Alkynyl HNE is a surrogate for endogenously generated HNE, a product of lipid oxidation and indicator or oxidative stress.
Highlights:
- The alkyne moiety allows the compound to be reacted with a fluorescent or biotin label via copper-catalyzed click chemistry for visualization and/or enrichment techniques
From the laboratory of Ned A. Porter, PhD and Keri A. Tallman, PhD, Vanderbilt University.
Alkynyl HNE is a surrogate for endogenously generated HNE, a product of lipid oxidation and indicator or oxidative stress.
Highlights:
- The alkyne moiety allows the compound to be reacted with a fluorescent or biotin label via copper-catalyzed click chemistry for visualization and/or enrichment techniques
From the laboratory of Ned A. Porter, PhD and Keri A. Tallman, PhD, Vanderbilt University.
Specifications
| Product Type: | Small Molecule |
| Name: | Alkynyl 4-hydroxy-2-nonenal (aHNE) |
| Chemical Formula: | C9H12O2 |
| Source: | Synthetic |
| Molecular Weight: | 152.19 kDa |
| Format: | Solid |
| Solubility: | DMSO, EtOH |
| Storage: | -20C |
| Shipped: | Ambient temperature |
Provider
From the laboratory of Ned A. Porter, PhD and Keri A. Tallman, PhD, Vanderbilt University.
References
- Kim, HY. H, Tallman, KA, Liebler, DC, Porter, NA. An Azido-Biotin Reagent for Use in the Isolation of Protein Adducts of Lipid-Derived Electrophiles by Streptavidin Catch and Photo-Release. Mol. Cell. Proteomics 2009, 8, 2080.
- Codreanu, SG, Ullery, JC, Zhu, J, Tallman, KA, Beavers, WN, Porter, NA, Marnett, LJ, Zhang, B, Liebler, DC. Alkylation Damage by Lipid Electrophiles Targets Functional Protein Systems. Mol. Cell. Proteomics 2014, 13, 849.
- Vila, A, Tallman, KA,Jacobs, AT, Liebler, DC, Porter, NA, Marnett L. Identification of Protein Targets of 4-Hydroxynonenal Using Click Chemistry for ex Vivo Biotinylation of Azido and Alkynyl Derivatives. Chem. Res. Toxicol. 2008, 21, 432.
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