Dominant negative (D512K) protective antigen (PA), inactive mutant. This mutant PA cannot oligomerize. However, it can be complemented by PA GN or PA NS, with which it forms active octamers.
Anthrax toxin is a three-protein exotoxin secreted by virulent strains of the bacterium, Bacillus anthracis, the causative agent of anthrax. Anthrax toxin is composed of a cell-binding protein, known as protective antigen (PA), and two enzyme components, called edema factor (EF) and lethal factor (LF). Anthrax is caused by B. anthracis, a spore-forming, Gram positive, rod-shaped bacterium. The lethality of the disease is caused by the bacterium's two principal virulence factors: the polyglutamic acid capsule, which is anti-phagocytic, and the tripartite protein toxin, called anthrax toxin.
From the laboratory of Stephen H. Leppla, PhD, National Institute of Allergy and Infectious Diseases/NIH.
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|Alternative Name(s):||PA D512K|
|Strain:||Expressed in avirulent engineered B. anthracisstrain BH460|
|Format:||Purified protein (liquid)|
|Buffer:||5 mM Hepes pH 7.5, 0.50 mM EDTA|
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