The L687A mutant protective antigen (PA) binds preferentially to the CMG2 receptor vs. the TEM8 receptor.
Anthrax toxin is a three-protein exotoxin secreted by virulent strains of the bacterium, Bacillus anthracis, the causative agent of anthrax. Anthrax toxin is composed of a cell-binding protein, known as protective antigen (PA), and two enzyme components, called edema factor (EF) and lethal factor (LF). Anthrax is caused by B. anthracis, a spore-forming, Gram positive, rod-shaped bacterium. The lethality of the disease is caused by the bacterium's two principal virulence factors: the polyglutamic acid capsule, which is anti-phagocytic, and the tripartite protein toxin, called anthrax toxin.
From the laboratory of Stephen H. Leppla, PhD, National Institute of Allergy and Infectious Diseases/NIH.
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|Alternative Name(s):||PA L687A|
|Strain:||Expressed in avirulent engineered B. anthracisstrain BH445|
|Format:||Purified protein (liquid)|
|Purity:||Q-Sepharose Ion Exchange Chromatography|
|Buffer:||5 mM Hepes pH 7.5, 0.50 mM EDTA|
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