PA L687A (Anthrax Protective Mutant Antigen (PA-L687A))

The L687A mutant protective antigen (PA) binds preferentially to the CMG2 receptor vs. the TEM8 receptor.

Anthrax toxin is a three-protein exotoxin secreted by virulent strains of the bacterium, Bacillus anthracis, the causative agent of anthrax. Anthrax toxin is composed of a cell-binding protein, known as protective antigen (PA), and two enzyme components, called edema factor (EF) and lethal factor (LF). Anthrax is caused by B. anthracis, a spore-forming, Gram positive, rod-shaped bacterium. The lethality of the disease is caused by the bacterium's two principal virulence factors: the polyglutamic acid capsule, which is anti-phagocytic, and the tripartite protein toxin, called anthrax toxin.

From the laboratory of Stephen H. Leppla, PhD, National Institute of Allergy and Infectious Diseases/NIH.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
ENH009-LT
PA L687A (Anthrax Protective Mutant Antigen (PA-L687A))
100ug (6.24mg/mL) In stock
Regular Price:$306.00
On Sale:

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Specifications

Product Type: Protein
Name: L678A
Alternative Name(s): PA L687A
Strain: Expressed in avirulent engineered B. anthracisstrain BH445
Format: Purified protein (liquid)
Purity: Q-Sepharose Ion Exchange Chromatography
Buffer: 5 mM Hepes pH 7.5, 0.50 mM EDTA
Concentration: 6.24mg/mL
Storage: -80C
Shipped: Dry ice

Provider
From the laboratory of Stephen H. Leppla, PhD, National Institute of Allergy and Infectious Diseases/NIH.
References
  1. Leppla SH. Production and purification of anthrax toxin. Methods Enzymol. 1988;165:103-16.
  2. Liu, S., Zhang, Y., Moayeri, M., Liu, J., Crown, D., Fattah, R. J., Wein, A. N., Yu, Z. X., Finkel, T., and Leppla, S. H. (2013) Key tissue targets responsible for anthrax-toxin-induced lethality. Nature 501, 63-68

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