Anti-Integrin Beta 3 (GPIIIa, CD61) [MBC 319.4] Antibody

This IgG2b mouse monoclonal (MBC 319.4) was generated against human glycoprotein IIIa and is specific for the EGF repeats domain of human glycoprotein IIIa (GPIIIa; CD61) when integrin is in a complex with RDG containing peptides.

Highlights:

  • Reacts with human glycoprotein IIIa
  • Ligand Binding Site (LIBS) antibody
  • Suitable for Flow Cytometry

Glycoprotein IIb/IIIa, also known as integrin aIIbß3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder.

From the laboratory of Richard H. Aster, MD, PhD, Blood Center of Wisconsin

The Investigator's Annexe Part of The Investigator's Annexe program.

Catalog Number Product Size AVAILABILITY Price Qty
EBW108
Anti-Integrin Beta 3 (GPIIIa, CD61) [MBC 319.4] Antibody
100ug 3-5 weeks
Regular Price:$321.00
Specifications

Product Type: Antibody
Antigen: Glycoprotein IIIa
Accession ID: P05106
Isotype: IgG2b
Clonality: Monoclonal
Clone Name: MBC 319.4
Reactivity: Human
Immunogen: EGF repeats
Species Immunized: Mouse
Purification Method: Protein G
Method Used to Determine Concentration: BCA
Buffer: PBS
Tested Applications: Flow Cytometry (0.01 mg/mL)
Concentration: 1 mg/mL
Storage: -20C
Shipped: Cold packs

Provider
From the laboratory of Richard H. Aster, MD, PhD, Blood Center of Wisconsin
References
  1. Chen Y, Ju LA, Zhou F, Liao J, Xue L, Su QP, Jin D, Yuan Y, Lu H, Jackson SP, Zhu C. An integrin α(IIb)β(3) intermediate affinity state mediates biomechanical platelet aggregation. Nat Mater. 2019 Mar 25. View Article

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