This IgG1 mouse monoclonal (AP2) was generated against human glycoprotein IIIa and is specific for the beta I domain of human platelet glycoprotein IIIa (GPIIIa; CD61) only when in complex with GPIIb (CD41).
Highlights:
Glycoprotein IIb/IIIa, also known as integrin aIIbß3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder.
From the laboratory of Richard H. Aster, MD, PhD, Blood Center of Wisconsin
Part of The Investigator's Annexe program.
Product Type: | Antibody |
Antigen: | Glycoprotein IIb/IIa |
Isotype: | IgG1 |
Clonality: | Monoclonal |
Clone Name: | AP2 |
Reactivity: | Human |
Immunogen: | Human platelet |
Species Immunized: | Mouse |
Purification Method: | Protein G |
Method Used to Determine Concentration: | BCA |
Buffer: | PBS |
Tested Applications: | Flow Cytometry (0.02 mg/mL), ELISA capture (10ug/mL) and detection (10ug/mL) |
Concentration: | 1mg/mL |
Storage: | -20C |
Shipped: | Cold packs |
Antibody | Domain |
Anti-Integrin Alpha-IIb (GPIIb, CD41) [MBC 132.1] | Glycoprotein IIb |
Anti-Integrin Alpha-IIb (GPIIb, CD41), Beta Propeller Domain [MBC 290.5] | Beta propeller |
Anti-Integrin Alpha-IIb (GPIIb, CD41), Calf-1 Domain [MBC 370.2] | Calf 1 |
Anti-Integrin Alpha-IIb (GPIIb, CD41), Calf-2 Light Chain [MBC 314.5] | Calf 2- light chain |
Anti-Integrin Beta 3 (GPIIIa, CD61) [MBC 319.4] | EGF repeats |
Anti-Integrin Beta 3 (GPIIIa, CD61), PSI Domain [AP-3] | PSI/Hybrid amino acids 50-62 |
Anti-Integrin Beta 3 (GPIIIa, CD61) [MBC 322.8] | EGF repeats |
Anti-Integrin Beta 3 (GPIIIa, CD61), PSI Domain [AP-5] | PSI amino acids 1-6 |
Anti-Glycoprotein GPIIIa/GPIIb Complex [AP-2] | Beta 1 |
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