Anti-Glycoprotein GPIIIa/GPIIb Complex [AP-2] Antibody

This IgG1 mouse monoclonal (AP2) was generated against human glycoprotein IIIa and is specific for the beta I domain of human platelet glycoprotein IIIa (GPIIIa; CD61) only when in complex with GPIIb (CD41).

Highlights:

  • Reacts with human glycoprotein IIIa
  • Suitable for ELISA and Flow Cytometry

Glycoprotein IIb/IIIa, also known as integrin aIIbß3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder.

From the laboratory of Richard H. Aster, MD, PhD, Blood Center of Wisconsin

The Investigator's Annexe Part of The Investigator's Annexe program.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
EBW105
Anti-Glycoprotein GPIIIa/GPIIb Complex [AP-2] Antibody
100ug In stock
Regular Price:$350.00
On Sale:
Specifications

Product Type: Antibody
Antigen: Glycoprotein IIb/IIa
Isotype: IgG1
Clonality: Monoclonal
Clone Name: AP2
Reactivity: Human
Immunogen: Human platelet
Species Immunized: Mouse
Purification Method: Protein G
Buffer: PBS, 0.05% (w/v) Sodium azide
Tested Applications: Flow Cytometry (0.02 mg/mL), ELISA capture (10ug/mL) and detection (10ug/mL)
Storage: -20C
Shipped: Cold packs

Provider
From the laboratory of Richard H. Aster, MD, PhD, Blood Center of Wisconsin
References
  1. Pidard D, Montgomery RR, Bennett JS, Kunicki TJ. Interaction of AP-2, a monoclonal antibody specific for the human platelet glycoprotein IIb-IIIa complex, with intact platelets. J Biol Chem. 1983 Oct 25;258(20):12582-6.

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