Anti-Integrin Alpha-IIb (GPIIb, CD41), Calf-1 Domain [MBC 370.2] Antibody

This IgG1 mouse monoclonal (MBC 370.2) was generated against human glycoprotein IIb and is specific for calf-1 domain of human glycoprotein IIb when integrin is in a complex with RDG containing peptides.

Highlights:

  • Reacts with human glycoprotein IIb
  • Ligand Induced Binding Site (LIBS) antibody
  • Suitable for Flow Cytometry

Glycoprotein IIb/IIIa, also known as integrin aIIbßis an integrin complex found on platelets. The complex acts as a receptor for both fibrogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder.

From the laboratory of Richard H. Aster, MD, PhD, Blood Center of Wisconsin

The Investigator's Annexe Part of The Investigator's Annexe program.

Catalog Number Product Size AVAILABILITY Price Qty
EBW104
Anti-Integrin Alpha-IIb (GPIIb, CD41), Calf-1 Domain [MBC 370.2] Antibody
100ug Currently unavailable
Regular Price:$321.00
Contact us for details.
Specifications

Product Type: Antibody
Antigen: Glycoprotein IIb
Accession ID: P08514
Isotype: IgG1
Clonality: Monoclonal
Clone Name: MBC 370.2
Reactivity: Human
Immunogen: Calf-1 domain
Species Immunized: Mouse
Purification Method: Protein G
Method Used to Determine Concentration: BCA
Buffer: PBS
Tested Applications: Flow Cytometry (0.01 mg/mL)
Concentration: 1mg/mL
Storage: -20C
Shipped: Cold packs

Provider
From the laboratory of Richard H. Aster, MD, PhD, Blood Center of Wisconsin
References
  1. Chen Y, Ju LA, Zhou F, Liao J, Xue L, Su QP, Jin D, Yuan Y, Lu H, Jackson SP, Zhu C. An integrin α(IIb)β(3) intermediate affinity state mediates biomechanical platelet aggregation. Nat Mater. 2019 Mar 25. View Article

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