Anti-Integrin Alpha-IIb (GPIIb, CD41), Beta Propeller Domain [MBC 290.5] Antibody

This IgG1 mouse monoclonal (MBC 290.5) was generated against human glycoprotein IIb and is specific for beta propeller domain of human glycoprotein IIb.

Highlights:

  • Reacts with human glycoprotein IIb
  • Suitable for Flow Cytometry

Glycoprotein IIb/IIIa, also known as integrin aIIbßis an integrin complex found on platelets. The complex acts as a receptor for both fibrogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder.

From the laboratory of Richard H. Aster, MD, PhD, Blood Center of Wisconsin

The Investigator's Annexe Part of The Investigator's Annexe program.

Catalog Number Product Size AVAILABILITY Price Qty
EBW103
Anti-Integrin Alpha-IIb (GPIIb, CD41), Beta Propeller Domain [MBC 290.5] Antibody
100ug In stock
Regular Price:$321.00
Specifications

Product Type: Antibody
Accession ID: P08514
Antigen: Glycoprotein IIb
Isotype: IgG1
Clonality: Monoclonal
Clone Name: MBC 290.5
Reactivity: Human
Immunogen: Beta propeller domain
Species Immunized: Mouse
Purification Method: Protein G
Method Used to Determine Concentration: BCA
Buffer: PBS
Tested Applications: Flow Cytometry (0.02 mg/mL)
Concentration: 1mg/mL
Storage: -20C
Shipped: Cold packs

Provider
From the laboratory of Richard H. Aster, MD, PhD, Blood Center of Wisconsin
References
  1. Padmanabhan A, Jones CG, Bougie DW, Curtis BR, McFarland JG, Wang D, Aster RH. Heparin-independent, PF4-dependent binding of HIT antibodies to platelets: implications for HIT pathogenesis. Blood. 2015 Jan 1;125(1):155-61. doi: 10.1182/blood-2014-06-580894. Epub 2014 Oct 23.

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