This IgG1 mouse monoclonal (clone 2A10) was generated against the catalytic subunit of human DNA polymerase eta and is specific for human DNA-polymerase Eta (Pol η).
DNA polymerase eta (Pol η) is a protein in humans encoded by the POLH gene, and is particularly important for allowing accurate translesion synthesis of DNA damage resulting from ultraviolet (UV) radiation. Mutations in the POLH gene can result in Xeroderma Pigmentosum (XP), an autosomonal recessive genetic disorder where the inherited are extremely sensitive to UV rays from sunlight.
From the laboratory of Aneel K. Aggarwal, PhD, Icahn School Of Medicine at Mount Sinai.
|Molecular Weight:||47.5 kDa|
|Immunogen:||Catalytic core of enzyme (amino acids 1-430)|
|Buffer:||0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide|
|Tested Applications:||ELISA, WB and IP|
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