Anti-Septin 9 [10C10] Antibody

This IgG1 mouse monoclonal antibody [10C10] is reactive against SEPT9.

Highlights:

  • Broad cross reactivity - Dog, Human, Mouse and Rat
  • Suitable for Immunoprecipitation and Immunofluorescence applications

Septins are a group of GTP-binding proteins found in eukaryotic cells and are known for their involvement in cytokinesis and cell cycle control. Septin 9 is widely expressed in many tissues and its major function is tumor suppression. Mutations in Sept9 gene have been linked to neuritis, hereditary neuralgic amytrophy and a wide range of cancers.

From the laboratory of William S. Trimble, PhD, FRSC, Hospital for Sick Children.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
ESK301
Anti-Septin 9 [10C10] Antibody
1.5mL (supernatant) In stock
Regular Price:$355.00
On Sale:
Specifications

Product Type: Antibody
Alternative Name(s): MLL septin-like fusion protein MSF-A, Septin D1, Ovarian/Breast septin
Accession ID: NP006631.2
Antigen: Septin 9 (SEPT9)
Molecular Weight: 64 kDa
Isotype: IgG1
Clonality: Monoclonal
Clone Name: 10C10
Reactivity: Dog, human, mouse and rat
Immunogen: Recombinant protein
Species Immunized: Mouse
Buffer: Cell culture supernatant
Tested Applications: IF (1:10-1:50), IP (1:10-1:50)
Concentration: 20 mg/mL
Storage: 4C short term, -80C long term (avoid freeze-thaw cycles)
Shipped: Dry ice

Data

Confocal Microscopy

Hela cells were co-stained with Hoechst (blue), 10C10 (green) and a Sept9 polyclonal antibody. The two antibodies recognize the same structures, proving evidence that 10C10 specifically recognizes SEPT9.

Adapted from: Etsey MP et al., J Cell Biol. 2010 Nov 15;191(4):741-9.
Provider
From the laboratory of William S. Trimble, PhD, FRSC, Hospital for Sick Children.
References
  1. Estey MP, Di Ciano-Oliveira C, Froese CD, Bejide MT, Trimble WS. Distinct roles of septins in cytokinesis: SEPT9 mediates midbody abscission. J Cell Biol. 2010 Nov 15;191(4):741-9.
  2. Estey MP, Di Ciano-Oliveira C, Froese CD, Fung KY, Steels JD, Litchfield DW, Trimble WS. Mitotic regulation of SEPT9 protein by cyclin-dependent kinase 1 (Cdk1) and Pin1 protein is important for the completion of cytokinesis. J Biol Chem. 2013 Oct 18;288(42):30075-86.

If you publish research with this product, please let us know so we can cite your paper.

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