This IgG1 mouse monoclonal antibody [10C10] is reactive against SEPT9.
Septins are a group of GTP-binding proteins found in eukaryotic cells and are known for their involvement in cytokinesis and cell cycle control. Septin 9 is widely expressed in many tissues and its major function is tumor suppression. Mutations in Sept9 gene have been linked to neuritis, hereditary neuralgic amytrophy and a wide range of cancers.
From the laboratory of William S. Trimble, PhD, FRSC, Hospital for Sick Children.
|Alternative Name(s):||MLL septin-like fusion protein MSF-A, Septin D1, Ovarian/Breast septin|
|Antigen:||Septin 9 (SEPT9)|
|Molecular Weight:||64 kDa|
|Reactivity:||Dog, human, mouse and rat|
|Buffer:||Cell culture supernatant|
|Tested Applications:||IF (1:10-1:50), IP (1:10-1:50)|
|Storage:||4C short term, -80C long term (avoid freeze-thaw cycles)|
Hela cells were co-stained with Hoechst (blue), 10C10 (green) and a Sept9 polyclonal antibody. The two antibodies recognize the same structures, proving evidence that 10C10 specifically recognizes SEPT9.Adapted from: Etsey MP et al., J Cell Biol. 2010 Nov 15;191(4):741-9.
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