Anti-Septin 9 [10C10] Antibody
![Anti-Septin 9 [10C10] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/867_200120200126258660.jpg "Anti-Septin 9 [10C10] Antibody")
This IgG1 mouse monoclonal antibody [10C10] is reactive against SEPT9.
Highlights:
- Broad cross reactivity - Dog, Human, Mouse and Rat
- Suitable for Immunoprecipitation and Immunofluorescence applications
Septins are a group of GTP-binding proteins found in eukaryotic cells and are known for their involvement in cytokinesis and cell cycle control. Septin 9 is widely expressed in many tissues and its major function is tumor suppression. Mutations in Sept9 gene have been linked to neuritis, hereditary neuralgic amytrophy and a wide range of cancers.
From the laboratory of William S. Trimble, PhD, FRSC, Hospital for Sick Children.
This IgG1 mouse monoclonal antibody [10C10] is reactive against SEPT9.
Highlights:
- Broad cross reactivity - Dog, Human, Mouse and Rat
- Suitable for Immunoprecipitation and Immunofluorescence applications
Septins are a group of GTP-binding proteins found in eukaryotic cells and are known for their involvement in cytokinesis and cell cycle control. Septin 9 is widely expressed in many tissues and its major function is tumor suppression. Mutations in Sept9 gene have been linked to neuritis, hereditary neuralgic amytrophy and a wide range of cancers.
From the laboratory of William S. Trimble, PhD, FRSC, Hospital for Sick Children.
| Product Type: | Antibody |
| Alternative Name(s): | MLL septin-like fusion protein MSF-A, Septin D1, Ovarian/Breast septin |
| Antigen: | Septin 9 (SEPT9) |
| Accession ID: | Q9UHD8, NP_006631.2 |
| Molecular Weight: | 64 kDa |
| Isotype: | IgG1 |
| Clonality: | Monoclonal |
| Clone Name: | 10C10 |
| Reactivity: | Dog, human, mouse and rat |
| Immunogen: | Recombinant protein |
| Species Immunized: | Mouse |
| Buffer: | Cell culture supernatant |
| Tested Applications: | IF (1:10-1:50), IP (1:10-1:50) |
| Concentration: | 20 mg/mL |
| Storage: | 4C short term, -80C long term (avoid freeze-thaw cycles) |
| Shipped: | Cold Packs |
Confocal Microscopy
Hela cells were co-stained with Hoechst (blue), 10C10 (green) and a Sept9 polyclonal antibody. The two antibodies recognize the same structures, proving evidence that 10C10 specifically recognizes SEPT9.
Adapted from: Etsey MP et al., J Cell Biol. 2010 Nov 15;191(4):741-9.- Estey MP, Di Ciano-Oliveira C, Froese CD, Bejide MT, Trimble WS. Distinct roles of septins in cytokinesis: SEPT9 mediates midbody abscission. J Cell Biol. 2010 Nov 15;191(4):741-9.
- Estey MP, Di Ciano-Oliveira C, Froese CD, Fung KY, Steels JD, Litchfield DW, Trimble WS. Mitotic regulation of SEPT9 protein by cyclin-dependent kinase 1 (Cdk1) and Pin1 protein is important for the completion of cytokinesis. J Biol Chem. 2013 Oct 18;288(42):30075-86.
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