This IgG1 kappa mouse monoclonal antibody [11B7] is reactive against the capsular polysaccharide of F. tularensis.
Francisella tularensis is a small pathogenic gram-negative, nonmotile, aerobic bacteria and the causative agent of tularemia. Also known as "rabbit fever" the highly contagious bacteria can be spread from animals to humans, through a vector such as fleas or mosquitoes. F. tularensis has been considered to be encapsulated for over 40 years based on the rough colony phenotype and presence of polysachharides structures on the organism. Francisella tularensis is classified as a Category A biological agent and symptoms include fever, headache and body aches.
From the laboratory of Michael A. Apicella, MD, University of Iowa.
Part of The Investigator's Annexe program.
|Molecular Weight:||100-250 kDa|
|Immunogen:||Membranes prepared from F. tularensisstrain SchuS4|
|Buffer:||0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide|
|Tested Applications:||WB, ELISA, IF|
Western blot of six F. tularensis strains
Monoclonal antibody 11B7 binds to capsule from lysates of five F. tularensis strains (lanes 1-5) and F. tularensis subsp holarcita 1547 (lane 6).
Adapted from: Apicella MA,. et al. PLoS One. 2010 Jul 6;5(7):e11060.
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