This mouse IgG1 monoclonal antibody was generated against SARS-CoV Spike Protein and recognizes SARS virus infected samples.
It has recently been shown that SARS (severe acute respiratory syndrome) is caused by a human coronavirus. Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive stranded RNA approximately 27 to 31kb in length. SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin converting enzyme 2 (ACE2) on target cells.
From the laboratory of John W. Kappler, PhD and Philippa Marrack, PhD, National Jewish Health.
|Antigen:||SARS-CoV spike protein|
|Accession ID:||P0DTC2, AAP41037|
|Molecular Weight:||180 kDa|
|Reactivity:||Reacts with samples infected with SARS virus|
|Immunogen:||Full length SARS-CoV spike protein expressed in HEK293 cell line (Preparation is described in Cell Res. 2008 Feb;18(2):290-301.)|
|Species Immunized:||Balb/c mouse|
|Purification Method:||Protein G column|
|Buffer:||0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide|
|Tested Applications:||WB, ELISA|
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