This mouse IgG1 monoclonal antibody was generated against HIV-1 gp160 and recognizes HIV-1 infected samples.
HIV-1 glycoprotein gp160 is cleaved into two chains: surface protein gp120, and transmembrane protein gp41. The surface protein gp120 attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. The transmembrane protein gp41 acts as a class I viral fusion protein. Inhibitors targeting HIV-1 viral envelope proteins are often used as antiretroviral drugs.
From the laboratory of John W. Kappler, PhD and Philippa Marrack, PhD, National Jewish Health.
Part of The Investigator's Annexe program.
|Antigen:||HIV-1 glycoprotein 160|
|Molecular Weight:||220 kDa|
|Reactivity:||Reacts with HIV infected human samples|
|Immunogen:||HIV-1 gp140 protein expressed in HEK 293 cells|
|Species Immunized:||Balb/c mouse|
|Purification Method:||Protein G column|
|Buffer:||0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide|
|Tested Applications:||WB (1:1000), ELISA|
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