This rabbit IgG polyclonal antibody was generated against the entire ectodomain of ADAM28 including the EGF repeat fused to the Fc domain of human IgG and is specific for the extracellular domain of mouse ADAM28.
The ADAM (A Disintegrin And Metalloprotease Domain) family is a unique group of proteins that has the ability to cleave or shed extracellular portions of transmembrane proteins. In addition, ADAMs are involved in cell-cell and cell-matrix interactions (e.g., fertilization, muscle development and neurogenesis).
Based on sequence identity, ADAM28 is more closely related to snake venom metalloproteases (SVMPs) than to presently known ADAMs. Northern blot analysis revealed ADAM28 is expressed in the epididymis, suggesting a possible role in sperm maturation, and in the lung. Mature ADAM28 is presumed to be catalytically active and found mainly on the cell surface.
From the laboratory of Carl P. Blobel, MD, PhD, Hospital for Special Surgery.
|Antigen:||GST-ADAM28 Cytoplasmic Domain|
|Molecular Weight:||~100 kDa|
|Immunogen:||Entire ectodomain of mouse ADAM28 including the EGF repeat fused to the Fc domain of human IgG1|
|Purification Method:||Serum, not purified|
|Tested Applications:||WB (1:500), only on non-reduced samples (no DTT or BME)|
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