Anti-ADAM19 (mouse), Cytoplasmic Domain Antibody

This rabbit IgG polyclonal antibody was generated against the GST-ADAM19-cytoplasmic tail and is specific for the cytoplasmic domain of mouse ADAM19.

The ADAM (A Disintegrin And Metalloprotease Domain) family is a unique group of proteins that has the ability to cleave or shed extracellular portions of transmembrane proteins. In addition, ADAMs are involved in cell-cell and cell-matrix interactions (e.g., fertilization, muscle development and neurogenesis).

ADAM19, also known as meltrin ß, was first identified in muscle cells and later expressed in other tissues (e.g. heart, lung and bone). The catalytic activity of ADAM19 has been explored by the overexpression in cells and by purifying recombinantly expressed soluble forms of the ectodomain or the pro- and metalloproteinase domains. ADAM19 has an important role during cardiovascular morphogenesis.

From the laboratory of Carl P. Blobel, MD, PhD, Hospital for Special Surgery.

The Investigator's Annexe Part of The Investigator's Annexe program.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
Anti-ADAM19 (mouse), Cytoplasmic Domain Antibody
100uL In stock
Regular Price:$345.00
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Product Type: Antibody
Antigen: GST-ADAM19 Cytoplasmic Domain
Accession ID: Q9H013
Molecular Weight: ~120 kDa
Isotype: IgG
Clonality: Polyclonal
Reactivity: Mouse
Immunogen: GST-fusion protein with the cytoplasmic domain of mouse ADAM19
Species Immunized: Rabbit
Epitope: Cytoplasmic domain
Purification Method: Serum, not purified
Tested Applications: WB (1:500)
Storage: -80C
Shipped: Dry ice

Antibody Species Reactivity Specificity
ADAM9 Human Cytoplasmic Domain
ADAM9 Mouse Cytoplasmic Domain
ADAM12 Mouse Cytoplasmic Domain
ADAM15 Human Cytoplasmic Domain
ADAM15 Mouse Cytoplasmic Domain
ADAM15 Human Extracellular Domain
ADAM15 Mouse Disintegrin Domain
ADAM17 Mouse Cytoplasmic Domain
ADAM17 Mouse Pro domain
ADAM19 Mouse Cytoplasmic Domain
ADAM28 Mouse Cytoplasmic Domain
ADAM28 Mouse Extracellular Domain
SNX9 Mouse Cytoplasmic Domain

Western Blot Analysis

Western blot analysis of mouse primary osteoblasts probed with whole ADAM19 antiserum at a 1:500 dilution.

Adapted from: Inoue E, et al. J. Biol. Chem. 1998, 273, 4180-4187.

From the laboratory of Carl P. Blobel, MD, PhD, Hospital for Special Surgery.
  1. Inoue, D.; Reid, M.; Lum, L.; Krätzschmar, J.; Weskamp, G.; Myung, Y. M.; Baron, R.; Blobel, C. P. Cloning and initial characterization of mouse meltrin beta and analysis of the expression of four metalloprotease-disintegrins in bone cells. J. Biol. Chem. 1998, 273, 4180-4187.
  2. Chesneau, V.; Becherer, J. D.; Zheng, Y.; Erdjument-Bromage, H.; Tempst, P.; Blobel, C. P. Catalytic properties of ADAM19. J. Biol. Chem. 2003, 278, 22331-22340.
  3. Zhou, H. M.; Weskamp, G.; Chesneau, V.; Sahin, U.; Vortkamp, A.; Horiuchi, K.; Chiusaroli, R.; Hahn, R.; Wilkes, D.; Fisher, P.; Baron, R.; Manova, K.; Basson, C. T.; Hempstead, B.; Blobel, C. P. Essential role for ADAM19 in cardiovascular morphogenesis. Mol. Cell. Biol. 2004, 24, 96-104.
  4. Kawaguchi, N.; Horiuchi, K.; Becherer, J. D.; Toyama, Y.; Besmer, P.; Blobel, C. P. Different ADAMs have distinct influences on Kit ligand processing: phorbol-ester-stimulated ectodomain shedding of Kitl1 by ADAM17 is reduced by ADAM19. J. Cell. Sci. 2007, 120, 943-952.

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