Anti-ADAM17 (mouse), Pro Domain Antibody

This rabbit IgG polyclonal antibody was generated against the pro-domain of mouse ADAM17 and is specific for the pro-domain of mouse ADAM17.

The ADAM (A Disintegrin And Metalloprotease Domain) family is a unique group of proteins that has the ability to cleave or shed extracellular portions of transmembrane proteins. In addition, ADAMs are involved in cell-cell and cell-matrix interactions (e.g., fertilization, muscle development and neurogenesis).

ADAM17 (also referred to as Tumor Necrosis Factor Convertase, TACE) is involved in the processing of tumor necrosis factor alpha (TNF-a) at the surface of the cell, and is also required for shedding several ligands of the epidermal growth factor receptor and many other membrane proteins. The prodomain of catalytically active ADAMs is thought to act as an inhibitor of the protease via a cysteine-switch mechanism. Prodomain removal is therefore thought to be a prerequisite for ADAM17 protease activity.

From the laboratory of Carl P. Blobel, MD, PhD, Hospital for Special Surgery.

The Investigator's Annexe Part of The Investigator's Annexe program.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
Anti-ADAM17 (mouse), Pro Domain Antibody
100uL In stock
Regular Price:$345.00
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Product Type: Antibody
Antigen: ADAM17 Pro-Domain
Accession ID: P78536
Molecular Weight: ~120 kDa
Isotype: IgG
Clonality: Polyclonal
Reactivity: Mouse
Immunogen: Pro-domain of mouse ADAM17
Species Immunized: Rabbit
Epitope: Pro-domain
Purification Method: Serum, not purified
Tested Applications: WB (1:250)
Storage: -80C
Shipped: Dry ice

Antibody Species Reactivity Specificity
ADAM9 Human Cytoplasmic Domain
ADAM9 Mouse Cytoplasmic Domain
ADAM12 Mouse Cytoplasmic Domain
ADAM15 Human Cytoplasmic Domain
ADAM15 Mouse Cytoplasmic Domain
ADAM15 Human Extracellular Domain
ADAM15 Mouse Disintegrin Domain
ADAM17 Mouse Cytoplasmic Domain
ADAM17 Mouse Pro domain
ADAM19 Mouse Cytoplasmic Domain
ADAM28 Mouse Cytoplasmic Domain
ADAM28 Mouse Extracellular Domain
SNX9 Mouse Cytoplasmic Domain

Western Blot Analysis

Antibodies against: pro-domain fused to GST (α-PRO), cytoplasmic domain fused to GST (α-CYTO).

Adapted from: Schlöndorff J, et al. JBiochem J. 2000, 347, 131-138.

From the laboratory of Carl P. Blobel, MD, PhD, Hospital for Special Surgery.
  1. Schlöndorff, J.; Becherer, J. D.; Blobel, C. P. Intracellular maturation and localization of the tumour necrosis factor alpha convertase (TACE). Biochem J. 2000, 347, 131-138.
  2. McIlwain DR, Lang PA, Maretzky T, Hamada K, Ohishi K, Maney SK, Berger T, Murthy A, Duncan G, Xu HC, Lang KS, Häussinger D, Wakeham A, Itie-Youten A, Khokha R, Ohashi PS, Blobel CP, Mak TW. iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS. Science. 2012 Jan 13;335(6065):229-32.

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