This rabbit IgG polyclonal antibody was generated against an extracellular domain fusion protein of human ADAM15 with an IgG Fc domain and is specific for the extracellular domain of human ADAM15.
The ADAM (A Disintegrin And Metalloprotease Domain) family is a unique group of proteins that has the ability to cleave or shed extracellular portions of transmembrane proteins. In addition, ADAMs are involved in cell-cell and cell-matrix interactions (e.g., fertilization, muscle development and neurogenesis).
ADAM15 (Metargidin) is a membrane-anchored glycoprotein that has been implicated in pathological neovascularization and prostate cancer metastasis.
From the laboratory of Carl P. Blobel, MD, PhD, Hospital for Special Surgery.
Part of The Investigator's Annexe program.
|Antigen:||ADAM15 Extracellular Domain with IgG Fc Domain|
|Molecular Weight:||~100 kDa|
|Immunogen:||Extracellular Domain fusion protein of human ADAM15 with an IgG Fc Domain|
|Purification Method:||Serum, not purified|
|Tested Applications:||Western blot, only works on non-reduced samples (no DTT or BME) 1:500|
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