This rabbit IgG polyclonal antibody was generated against the GST-ADAM15-cytoplasmic tail and is specific for the cytoplasmic domain of mouse ADAM15.
The ADAM (A Disintegrin And Metalloprotease Domain) family is a unique group of proteins that has the ability to cleave or shed extracellular portions of transmembrane proteins. In addition, ADAMs are involved in cell-cell and cell-matrix interactions (e.g., fertilization, muscle development and neurogenesis).
ADAM15 (Metargidin) is a membrane-anchored metalloproteinase that has been implicated in pathological neovascularization and prostate cancer metastasis.
From the laboratory of Carl P. Blobel, MD, PhD, Hospital for Special Surgery.
Part of The Investigator's Annexe program.
|Antigen:||GST-ADAM15 cytoplasmic domain|
|Molecular Weight:||~100 kDa|
|Immunogen:||GST-cyto corresponding to the cytoplasmic domain of mouse ADAM15|
|Purification Method:||Serum, not purified|
|Tested Applications:||WB (1:500)|
Western Blot Analysis
Western blot of reduced glycoproteins from the indicated tissues were probed with ADAM15 cytoplasmic domain antibody.
Adapted from: Lum L, et al. J. Biol Chem. 1998, 273, 26236-26247.
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