This rabbit IgG polyclonal antibody was generated against the GST-ADAM12-cytoplasmic tail and is specific for the cytoplasmic domain of mouse ADAM12.
The ADAM (A Disintegrin And Metalloprotease Domain) family is a unique group of proteins that has the ability to cleave or shed extracellular portions of transmembrane proteins. In addition, ADAMs are involved in cell-cell and cell-matrix interactions (e.g., fertilization, muscle development and neurogenesis).
Like the other ADAM members, ADAM12 is structurally related to snake venom disintegrins. It has two alternatively spliced transcripts: a shorter secreted form and a longer membrane-bound form. ADAM12 has been implicated in breast and prostate cancer.
From the laboratory of Carl P. Blobel, MD, PhD, Hospital for Special Surgery.
Part of The Investigator's Annexe program.
|Antigen:||GST-ADAM12 cytoplasmic domain|
|Immunogen:||GST-cyto corresponding to the cytoplasmic domain of mouse ADAM12|
|Purification Method:||Serum, not purified|
|Tested Applications:||WB (1:500)|
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