Anti-NORE1A [10F10-C6-C6] Antibody

This mouse IgG1 antibody was generated against amino acids 119-416 of human NORE1A and the epitope has been mapped to amino acids 119-190, a unique sequence in the NORE1A splice isoform.

NORE1 (novel Ras effector 1) is a growth and tumor suppressor that is inactivated in a variety of cancers. Full-length NORE1 is 47 kDa and contains a proline-rich region at its N terminus, a putative diacylglycerol/phorbol ester-binding domain, and a C-terminal canonical Ras binding domain. The human NORE1 gene encodes several isoforms, of which NORE1A and NORE1B are the most prominent.

From the laboratory of Andrei Khokhlatchevz, PhD, University of Virginia.

The Investigator's Annexe Part of The Investigator's Annexe program.

Catalog Number Product Size AVAILABILITY Price Qty
EG5001
Anti-NORE1A [10F10-C6-C6] Antibody
100ug In stock
Regular Price:$356.00
Specifications

Product Type: Antibody
Name: Anti-NORE1A, Human (10F10-C6-C6) Monoclonal Antibody
Host: mouse
Isotype: IgG1
Clonality: Monoclonal
Clone Name: 10F10-C6-C6
Specificity: Recognizes human NORE1A
Immunogen: Generated against amino acids 119-416 of human NORE1A
Format: Liquid
Purity: Protein G affinity purified
Tested Applications: WB, IF
Concentration: 1mg/mL
Amount: 100uL
Storage: Store at 4C
Shipped: Cold packs

Data

Expression of human NORE1A in human cells. Cells were lysed in radioimmune precipitation (RIPA) buffer, and an equal amount of protein was separated by polyacrylamide gel and probed on Western blot with anti-NORE1A monoclonal antibody 10F10 (upper panel) or for alpha-tubulin (lower panel).

Adapted from: Moshnikova A, Frye J, Shay JW, Minna JD, Khokhlatchev AV. The growth and tumor suppressor NORE1A is a cytoskeletal protein that suppresses growth by inhibition of the ERK pathway. The Journal of Biological Chemistry. 281(12): 8143-8152 (2006).

Provider
From the laboratory of Andrei Khokhlatchevz, PhD, University of Virginia.
References
  1. Moshnikova A, Frye J, Shay JW, Minna JD, Khokhlatchev AV. The growth and tumor suppressor NORE1A is a cytoskeletal protein that suppresses growth by inhibition of the ERK pathway. The Journal of Biological Chemistry. 281(12): 8143-8152 (2006).

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