Anti-CD40 [626] Antibody

This mouse IgG1 antibody was generated against human activated tonsillar B cells and is specific for human CD40.

B cells require a series of coordinated signals in order to undergo maturation including MHC antigen presentation, cytokine stimulation (IL-2/4/5) and costimulation. CD40 is a costimulatory protein found on antigen presenting cells (such as B Cells) and is required for their activation. The binding of CD154 (CD40L) on T helper cells to the CD40 receptor stimulates antigen presenting cells to undergo maturity and develop downstream effector functions.

From the laboratory of Shu-Man Fu, MD, University of Virginia.

The Investigator's Annexe Part of The Investigator's Annexe program.

Catalog Number Product Size AVAILABILITY Price Qty
EG2002
Anti-CD40 [626] Antibody
100ug 2-3 weeks
Regular Price:$362.00
Specifications

Product Type: Antibody
Name: Anti-CD40, Human S19 (626)
Host: mouse
Isotype: IgG1
Clonality: Monoclonal
Clone Name: 626
Specificity: Human CD40
Immunogen: Generated against human activated tonsillar B cells
Format: Liquid
Purity: Protein G affinity purified
Tested Applications: FC, IHC, WB
Concentration: 1mg/mL
Amount: 100uL
Storage: Store at -20C
Shipped: Cold packs

Provider
From the laboratory of Shu-Man Fu, MD, University of Virginia.
Comments

Immunopreclpltatlons wlth detergent extracts of 125I-labeled tonsillar B cells. Lysates were treated with complexes of goat anti-mouse with anti-CD40-626 mAb and goat anti-mouse Ig. The precipitates were run on a 10% SDS-PAGE under reducing conditions. Control Ig mAb HDP-1 (lane a) and anti-CD40-626 (lane b).

Adapted from: Gruber MF, Bjorndahl JM, Nakamura S, Fu SM. Anti-CD45 inhibition of human B cell proliferation depends on the nature of activation signals and the state of B cell activation. J Immunol, 142(12):4144-4152, (1989).

References
  1. Gruber MF, Bjorndahl JM, Nakamura S, Fu SM. Anti-CD45 inhibition of human B cell proliferation depends on the nature of activation signals and the state of B cell activation. J Immunol, 142(12):4144-4152, (1989).

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