Anti-BTK [10D11] Antibody

This mouse IgG1 antibody was generated against the PH domain (amino acids 1-175) of human BTK.

BTK (Bruton's tyrosine kinase), also known as BPK or ATK, is a member of the TEC family of non-receptor protein tyrosine kinase which includes Bmx, Itk and TEC. BTK plays a crucial role in B cell activation and development. Similar to Etk-TNFR2 interaction, Btk interacts with Fas, a member of the TNFR family involved in apoptosis in a ligand-independent manner. Mutations in the Btk gene have been linked to severe developmental blocks in human B-cell ontogeny leading to X-linked agammaglobulinemia (XLA).

From the laboratory of Shu-Man Fu, MD, University of Virginia.

The Investigator's Annexe Part of The Investigator's Annexe program.

Catalog Number Product Size AVAILABILITY Price Qty
EG2001
Anti-BTK [10D11] Antibody
100ug 2-3 weeks
Regular Price:$362.00
Specifications

Product Type: Antibody
Name: Anti-BTK, Human (10D11)
Host: mouse
Isotype: IgG1
Clonality: Monoclonal
Clone Name: 10D11
Specificity: Human BTK
Immunogen: Generated against the PH domain (amino acids 1-175 of human BTK)
Format: Liquid
Purity: Protein G affinity purified
Tested Applications: WB, IP
Concentration: 1mg/mL
Amount: 100uL
Storage: Store at -20C
Shipped: Cold packs

Provider
From the laboratory of Shu-Man Fu, MD, University of Virginia.
Comments

Expression of Btk in normal and patient PBMC. The protein levels of Btk in total PBMC and fractionated cell populations were examined by western blotting. PBMC and purified monocytes (M), T cells (T), and B cells (B) from the same buffy coat were used. The numbers above the lanes indicate the number of cells x 106 used in each assay. Arrow indicates the position of Btk.

Adapted from: Bykowsky MJ, Haire RN, Ohta Y, Tang H, Sung SS, Veksler EG, Greene JM, Fu SM, Litman GW, Sullivan KE. Discordant phenotype in siblings with X-linked agammaglobulinemia. Am J Hum Genet, 58(3):477-483, (1996).

References
  1. Bykowsky MJ, Haire RN, Ohta Y, Tang H, Sung SS, Veksler EG, Greene JM, Fu SM, Litman GW, Sullivan KE. Discordant phenotype in siblings with X-linked agammaglobulinemia. Am J Hum Genet, 58(3):477-483, (1996).

If you publish research with this product, please let us know so we can cite your paper.

Loading...