Anti-Complement C3 [1H8] Antibody

This mouse IgG1 antibody was generated against human C3b and iC3b bound to a carbohydrate matrix via the alternative pathway of complement activation and recognizes human C3, C3b, iC3b and C3d.

The complement system consists of a number of small proteins found in the blood, generally synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex.

Complement component 3 (C3) plays a central role in the activation of the complement system. C3 cleavage by C3-convertase produces C3b and iC3b. C3b leads to an inflamatory response and also covalently binds to microbial cell surfaces aiding in opsonization of the microbe. C3b can be further cleaved into C3c and C3d.

From the laboratory of Ronald P. Taylor, PhD, University of Virginia.

The Investigator's Annexe Part of The Investigator's Annexe program.

Catalog Number Product Size AVAILABILITY Price Qty
EG1005
Anti-Complement C3 [1H8] Antibody
100ug In stock
Regular Price:$356.00
Specifications

Product Type: Antibody
Name: Anti-Human, Primate Complement C3b, iC3b (1H8) Monoclonal Antibody
Host: mouse
Isotype: IgG1
Clonality: Monoclonal
Clone Name: 1H8
Specificity: Human C3, C3b and iC3b
Immunogen: generated against human C3b and iC3b bound to a carbohydrate matrix via the alternative pathway of complement activation
Format: Liquid
Purity: Protein G affinity purified
Tested Applications: IF, ELISA
Concentration: 1mg/mL
Amount: 100uL
Storage: Store at 4C
Shipped: Cold packs

Provider
From the laboratory of Ronald P. Taylor, PhD, University of Virginia.
References
  1. Tosic L, Sutherland WM, Kured J, Edberg JC, Taylor RP. Preperation of amonoclona antibodies to C3b by immunization with C3b(i)-sepharose. J Immunol Methods, 120(2):241-249, (1989).
  2. Biryukov S, Angov E, Landmesser ME, Spring MD, Ockenhouse CF, Stoute JA.Complement and Antibody-mediated Enhancement of Red Blood Cell Invasion andGrowth of Malaria Parasites. EBioMedicine. 2016 May 14. pii:S2352-3964(16)30198-0. View Article

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