Anti-Complement C3 [10C7] Antibody

This mouse IgG1 antibody was generated against human C3 and recognizes mouse and human homologs of C3 and its breakdown products C3b and iC3b.

The complement system consists of a number of small proteins found in the blood, generally synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex.

Complement component 3 (C3) plays a central role in the activation of the complement system. C3 cleavage by C3-convertase produces C3b and iC3b. C3b leads to an inflamatory response and also covalently binds to microbial cell surfaces aiding in opsonization of the microbe.

From the laboratory of Ronald P. Taylor, PhD, University of Virginia.

The Investigator's Annexe Part of The Investigator's Annexe program.

Catalog Number Product Size AVAILABILITY Price Qty
EG1001
Anti-Complement C3 [10C7] Antibody
100ug 2-3 weeks
Regular Price:$333.00
Specifications

Product Type: Antibody
Name: Anti-Human, Mouse Complement C3 (10C7) Monoclonal Antibody
Host: mouse
Isotype: IgG1
Clonality: Monoclonal
Clone Name: 10C7
Specificity: Mouse and human homologs of C3, C3b, and iC3b
Immunogen: Generated against human C3
Format: Liquid
Purity: Protein G affinity purified
Tested Applications: FC, ELISA
Concentration: 1mg/mL
Amount: 100uL
Storage: Store at 4C
Shipped: Cold packs

Provider
From the laboratory of Ronald P. Taylor, PhD, University of Virginia.
References
  1. Whipple EC, Ditto AH, Shanahan RS, Gatesman JJ, Little SF, Taylor RP, Lindorfer MA. Low dose of antigen coupled to anti-CR2 mAbs induce rapid and enduring IgG immune responses in mice and in cynomolgus monkeys. Mol Immunol, 444:377-388, (2007).

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