This mouse IgG1 antibody was generated against human C3 and recognizes mouse and human homologs of C3 and its breakdown products C3b and iC3b.
The complement system consists of a number of small proteins found in the blood, generally synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex.
Complement component 3 (C3) plays a central role in the activation of the complement system. C3 cleavage by C3-convertase produces C3b and iC3b. C3b leads to an inflamatory response and also covalently binds to microbial cell surfaces aiding in opsonization of the microbe.
From the laboratory of Ronald P. Taylor, PhD, University of Virginia.
Part of The Investigator's Annexe program.
|Name:||Anti-Human, Mouse Complement C3 (10C7) Monoclonal Antibody|
|Specificity:||Mouse and human homologs of C3, C3b, and iC3b|
|Immunogen:||Generated against human C3|
|Purification Method:||Protein G affinity purified|
|Buffer:||PBS, 0.05% (w/v) Sodium Azide|
|Tested Applications:||FC, ELISA|
|Storage:||Store at 4C|
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