This IgG1 mouse antibody was generated against bovine brain tubulin (amino acids 416-431) and recognizes mammalian homologs of beta tubulin types I, II, III, IV.
Microtubules are required for many well characterized functions in eukaryotic cells, including the movement of chromosomes in mitosis and meiosis, intracellular transport, establishment and maintenance of cellular morphology, cell growth, cell migration and morphogenesis in multicellular organisms. The building block of a microtubule is the tubulin subunit, a heterodimer of alpha and beta tubulin. Both of these monomers are found in all eukaryotes, and their sequences are highly conserved. The tubulin protein is a major target of drug molecules, and consequently, tubulin inhibitors have attracted great attention as antimitotic antitumor agents for chemotherapeutic use.
From the laboratories of Anthony Frankfurter, PhD and Anthony Spano, PhD, University of Virginia.
Part of The Investigator's Annexe program.
|Name:||Anti-Beta Tubulin; clone AA2|
|Specificity:||Beta Tubulin (all mammalian homologs)|
|Immunogen:||Generated against bovine brain tubulin (amino acids 416-431)|
|Purity:||Protein G affinity purified|
|Tested Applications:||WB, IHC, IP, IF|
|Storage:||Store at 4C|
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