This IgG2a mouse antibody was generated against amino acids 436-450 of beta tubulin type III and recognizes human, mouse, rat, and bovine homologs.
Microtubules are required for many well characterized functions in eukaryotic cells, including the movement of chromosomes in mitosis and meiosis, intracellular transport, establishment and maintenance of cellular morphology, cell growth, cell migration and morphogenesis in multicellular organisms. The building block of a microtubule is the tubulin subunit, a heterodimer of alpha and beta tubulin. Both of these monomers are found in all eukaryotes, and their sequences are highly conserved. The tubulin protein is a major target of drug molecules, and consequently, tubulin inhibitors have attracted great attention as antimitotic antitumor agents for chemotherapeutic use.
Class III beta-tubulin (TUBB3) is a mcrotuble element expressed exclusively in neurons, and is a popular identifier specific for neurons in nervous tissue. TUBB3 plasy a critical role in proper axon guidance and mantainance.
From the laboratories of Anthony Frankfurter, PhD and Anthony Spano, PhD, University of Virginia.
Part of The Investigator's Annexe program.
|Name:||Anti-Class III Beta Tubulin (Tubb3); clone 2G10|
|Specificity:||Class III Beta Tubulin (Human, Mouse, Rat, Bovine)|
|Immunogen:||Generated against amino acids 436-450 of Class III Beta Tubulin|
|Purity:||Protein G affinity purified|
|Tested Applications:||WB, IHC, IP, IF|
|Storage:||Store at 4C|
If you publish research with this product, please let us know so we can cite your paper.