Anti-eIF4G1 [4GR11] Antibody

This antibody was raised in mice against rat eIF4G1 (residues 96-600) that was expressed in and purified from Sf9 cells.

The initiation of translation is an important biological event and a variety of factors contribute to this process. Members of the Eukaryotic initiation factor 4G (eIF4G) translation factor family bind to the 5' mRNA cap and unwind the mRNA secondary structure.

eIF4G (eukaryotic translation initiation factor 4 gamma) is a protein involved in bringing mRNA to the ribosome for translation, in general based on mRNA's distinctive guanosine cap.The amino-terminal portion of eIF4G physically associates with eIF4E to stimulate the binding of eIF4E to the mRNA cap structure. eIF4G also interacts with eIF3 and eIF4A and serves as an adaptor molecule in the eIF4 complex. Moreover, eIF4G plays a role in internal ribosomal entry site (IRES)-mediated initiation of translation.

From the laboratory of Scot R. Kimball, PhD, Penn State College of Medicine

The Investigator's Annexe Part of The Investigator's Annexe program.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
EQ0004
Anti-eIF4G1 [4GR11] Antibody
100ug, 0.5mg/mL In stock
Regular Price:$360.00
On Sale:
Specifications

Product Type: Antibody
Name: Anti-eIF4G1 monoclonal antibody (4GR11)
Host: Mouse
Isotype: IgG
Clonality: Monoclonal
Clone Name: 4GR11
Specificity: This antibody recognizes human, mouse, rat, and pig eIF4G1
Immunogen: Fragment corresponding to approx. amino acids 96-600 of the rat protein
Format: Liquid
Purification Method: HiTrap Protein G HR chromatography
Tested Applications: Western blotting, ELISA, IP, and IF.
Concentration: 0.5mg/mL
Amount: 200ul
Storage: Store at 4C
Shipped: Cold packs

Provider
From the laboratory of Scot R. Kimball, PhD, Penn State College of Medicine
References
  1. Jamison, J.T., et al. Persistent redistribution of poly-adenylated mRNAs correlates with translation arrest and cell death following global brain ischemia and reperfusion. Neuroscience. 154: 504 - 20. 2008.

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