Anti-RNA Polymerase II [MARA 3] Hybridoma
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This hybridoma line produces a mouse anti-human RNA polymerase II monoclonal antibody (clone MARA 3) recognizing the C-terminal domain of RNA polymerase II.
Eukaryotes have three nuclear RNA polymerases (RNAPs) that are DNA-dependent: RNAP I, RNAP II, and RNAP III. RNAP II is responsible for the synthesis of all mRNA. The largest subunit of RNAP II, Rbp1, contains a C-terminal domain (CTD) that is a unique feature of RNAP II. The CTD is highly conserved amongst eukaryotes and plays an important role in all steps of transcription.
This hybridoma line produces a mouse anti-human RNA polymerase II monoclonal antibody (clone MARA 3) recognizing the C-terminal domain of RNA polymerase II.
Eukaryotes have three nuclear RNA polymerases (RNAPs) that are DNA-dependent: RNAP I, RNAP II, and RNAP III. RNAP II is responsible for the synthesis of all mRNA. The largest subunit of RNAP II, Rbp1, contains a C-terminal domain (CTD) that is a unique feature of RNAP II. The CTD is highly conserved amongst eukaryotes and plays an important role in all steps of transcription.
Specifications
| Product Type: | Antibody |
| Name: | Anti-RNA Polymerase II [MARA 3] Hybridoma |
| Cell Type: | Hybridoma Cell Line |
| Antigen: | RNA Polymerase II |
| Isotype: | IgM |
| Clonality: | Monoclonal |
| Clone Name: | MARA 3 |
| Reactivity: | Human |
| Specificity: | RNA Polymerase II |
| Immunogen: | RNA Polymerase II |
| Growth Conditions: | Dulbecco's Modified Eagles medium (DMEM) + 10% fetal bovine serum (FBS) + non-essential amino acid + sodium pyruvate + 50uM beta-mercaptoethanol |
| Cryopreservation: | Resuspend cells in DMEM, 20% FBS, and 10% DMSO. Store in liquid nitrogen. |
| Species Immunized: | Mouse |
| Storage: | Liquid Nitrogen |
| Shipped: | Dry Ice |
References
- J Biol. Chem. (1998) 273:4689-4694
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