Semkur-IM is a redox dye for easily assaying cell vitality in real-time.
Semkur-IM permeates live cells and fluoresces when the quenching component is cleaved off by cellular glutathione. Fluorescence intensity correlates with reduced glutathione (GSH) an indicator of cellular stress. The reduced/oxidized ratio (redox state) of glutathione typically exceeds 10:1 in healthy cells. Abnormal levels are associated with numerous pathologies including cancer, neurodegenerative diseases, cystic fibrosis, cardiovascular diseases, HIV and aging.
|Product Type:||Small Molecule|
|Alternative Name(s):||DSSQ-1 probe|
|Purity:||99% via HPLC|
|Compatible Cells:||NIH3T3 cells; cultured human cells; plasma; reacts blood components|
|Comments:||1mg (sufficient for a 96 well plate)|
|Storage:||Room temperature (powder); -20C resuspended|
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