Anti-Adenylate Cyclase Toxin [2F5] Antibody

This mouse IgG1 antibody was generated against Bordetella pertussis adenylate cyclase (AC) toxin and recognizes an epitope in the glycine and aspartate-rich nonapeptide repeat region (amino acids 1156-1489) of B. pertussis AC and other RTX family bacteria toxins.

Highlights:

  • Reacts with adenylate cyclase
  • Suitable for Western Blot applications

Adenylate Cyclase Toxin (ACT or Cya A) is one of several virulence factors produced by the bacterium Bordetella pertussis. This toxin invades eukaryotic cells and catalyzes the conversion of ATP into cyclic AMP (cAMP). This leads to inhibition of host cell immune function and macrophage death by apoptosis. The Adenylate Cyclase protein is composed of a catalytic domain (amino acids 1 to 400), a hydrophobic region (amino acids 500 to 700), a glycine/aspartate-rich repeat unit (amino acids 1000 to 1600), and the C-terminal domain (amino acids 1600-1706).

From the laboratory of Erik L. Hewlett, MD, University of Virginia.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
EG1034
Anti-Adenylate Cyclase Toxin [2F5] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
Specifications

Product Type: Antibody
Name: Anti-Adenylate Cyclase Toxin [2F5] Antibody
Antigen: Adenylate Cyclase Toxin
Isotype: IgG1
Clonality: Monoclonal
Clone Name: 2F5
Reactivity: Recognizes an epitope in the glycine and aspartate-rich nonapeptide repeat region (amino acids 1156-1489) of B. pertussis AC and other RTX family bacteria toxins
Immunogen: Generated against Bordetella pertussis Adenylate Cyclase toxin
Species Immunized: Mouse
Epitope: Glycine and aspartate-rich nonapeptide repeat region (amino acids 1156-1489)
Buffer: PBS, 0.05% Sodium Azide
Tested Applications: WB
Storage: -20C
Shipped: Cold packs

Provider
From the laboratory of Erik L. Hewlett, MD, University of Virginia.
References
  1. Lee SJ, Gray MC, Guo L, Sebo P, Hewlett EL. Epitope mapping of monoclonal antibodies against Bordetella pertussis adenylate cyclase toxin. Infect Immun. 1999 May;67(5):2090-5. doi: 10.1128/IAI.67.5.2090-2095.1999. PMID: 10225859; PMCID: PMC115942.

If you publish research with this product, please let us know so we can cite your paper.

Loading...