This mouse IgG1 antibody was generated against Bordetella pertussis adenylate cyclase (AC) toxin and recognizes an epitope in the glycine and aspartate-rich nonapeptide repeat region (amino acids 1156-1489) of B. pertussis AC and other RTX family bacteria toxins.
Adenylate Cyclase Toxin (ACT or Cya A) is one of several virulence factors produced by the bacterium Bordetella pertussis. This toxin invades eukaryotic cells and catalyzes the conversion of ATP into cyclic AMP (cAMP). This leads to inhibition of host cell immune function and macrophage death by apoptosis. The Adenylate Cyclase protein is composed of a catalytic domain (amino acids 1 to 400), a hydrophobic region (amino acids 500 to 700), a glycine/aspartate-rich repeat unit (amino acids 1000 to 1600), and the C-terminal domain (amino acids 1600-1706).
From the laboratory of Erik L. Hewlett, MD, University of Virginia.
|Name:||Anti-Adenylate Cyclase Toxin [2F5] Antibody|
|Antigen:||Adenylate Cyclase Toxin|
|Reactivity:||Recognizes an epitope in the glycine and aspartate-rich nonapeptide repeat region (amino acids 1156-1489) of B. pertussis AC and other RTX family bacteria toxins|
|Immunogen:||Generated against Bordetella pertussis Adenylate Cyclase toxin|
|Epitope:||Glycine and aspartate-rich nonapeptide repeat region (amino acids 1156-1489)|
|Buffer:||PBS, 0.05% Sodium Azide|
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