Anti-Adenosine Receptor A2a [7F6-G5-A2] Antibody
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This IgG2a mouse antibody was generated against human adenosine A2a receptor and recognizes the 3rd intracellular loop of human, mouse, rabbit, dog, and rat A2a homologs.
Highlights:
- Reacts with 3rd intracellular loop of human, mouse, rabbit, dog, and rat A2AR homologs
- Suitable for Western Blot, Immunohystochemistry and Flow Cytometry applications
The A2A adenosine receptor, also known as ADORA2A, is an adenosine receptor (one of its several receptor subtypes) that is a member of the G protein-coupled receptor (GPCR) family. Its activity is mediated by G proteins which activate adenylyl cyclase. A2A receptor is commonly found in basal ganglia, vasculature, T lymphocytes, and platelets. It is thought to protect against tissue inflammation through its ability to suppress the immune cells, and may play a role in myocardial oxygen demand regulation and increase of coronary circulation by vasodilation. Because its expression is also found in the brain, it may be an attractive target for research studies or treatments of insomnia, pain, depression, and Parkinson's disease.
From a laboratory at University of Virginia.
This IgG2a mouse antibody was generated against human adenosine A2a receptor and recognizes the 3rd intracellular loop of human, mouse, rabbit, dog, and rat A2a homologs.
Highlights:
- Reacts with 3rd intracellular loop of human, mouse, rabbit, dog, and rat A2AR homologs
- Suitable for Western Blot, Immunohystochemistry and Flow Cytometry applications
The A2A adenosine receptor, also known as ADORA2A, is an adenosine receptor (one of its several receptor subtypes) that is a member of the G protein-coupled receptor (GPCR) family. Its activity is mediated by G proteins which activate adenylyl cyclase. A2A receptor is commonly found in basal ganglia, vasculature, T lymphocytes, and platelets. It is thought to protect against tissue inflammation through its ability to suppress the immune cells, and may play a role in myocardial oxygen demand regulation and increase of coronary circulation by vasodilation. Because its expression is also found in the brain, it may be an attractive target for research studies or treatments of insomnia, pain, depression, and Parkinson's disease.
From a laboratory at University of Virginia.
| Product Type: | Antibody |
| Name: | Anti-Adenosine Receptor A2a [7F6-G5-A2] Antibody |
| Antigen: | Adenosine Receptor A2a |
| Accession ID: | P29274 |
| Molecular Weight: | 43kDa |
| Isotype: | IgG2a |
| Clonality: | Monoclonal |
| Clone Name: | 7F6-G5-A2 |
| Reactivity: | Rabbit, canine, human, mouse, rat, dog |
| Immunogen: | 6His-tagged full length human recombinant A2A receptor |
| Species Immunized: | Mouse |
| Buffer: | PBS, 0.05% Sodium Azide |
| Tested Applications: | WB, IHC, FC |
| Storage: | -20C |
| Shipped: | Cold packs |
- Koshiba M, Rosin DL, Hayashi N, Linden J, Sitkovsky MV. Patterns of A2A extracellular adenosine receptor expression in different functional subsets of human peripheral T cells. Flow cytometry studies with anti-A2A receptor monoclonal antibodies. Mol Pharmacol. 1999 Mar;55(3):614-24. PMID: 10051547.
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