Anti-Fascin 1 [55k-2] Antibody
This mouse IgG1 antibody was raised against Fascin 1 purified from HeLa cells and is reactive against mouse, rat and human tissue.
Fascin1 is an actin-binding protein, and crucial for filopodia formation cells, motile activites such as neurite growth and directed movement such as cell migration. In addition Fascin1 overexpression has been observed in various pathologies such as cutaneous and oral melanocytic tumors, esophageal squamous cell, hepatocellular and soft tissue carcinomas.
Cellular adhesion to the matrix glycoprotein Thrombospondin-1 triggers the formation of F-actin spikes that contain the Actin-bundling protein Fascin. Fascin is also implicated in cell migration by bundling Actin filaments. Fascin also identifies antigen presenting dendritic cells in the blood and in tissues and is a sensitive marker for Reed-Sternberg Cells of Hodgkin’s Disease.
From the laboratory of Fumio Matsumura, PhD, Rutgers University.
Part of The Investigator's Annexe program.
This mouse IgG1 antibody was raised against Fascin 1 purified from HeLa cells and is reactive against mouse, rat and human tissue.
Fascin1 is an actin-binding protein, and crucial for filopodia formation cells, motile activites such as neurite growth and directed movement such as cell migration. In addition Fascin1 overexpression has been observed in various pathologies such as cutaneous and oral melanocytic tumors, esophageal squamous cell, hepatocellular and soft tissue carcinomas.
Cellular adhesion to the matrix glycoprotein Thrombospondin-1 triggers the formation of F-actin spikes that contain the Actin-bundling protein Fascin. Fascin is also implicated in cell migration by bundling Actin filaments. Fascin also identifies antigen presenting dendritic cells in the blood and in tissues and is a sensitive marker for Reed-Sternberg Cells of Hodgkin’s Disease.
From the laboratory of Fumio Matsumura, PhD, Rutgers University.
Part of The Investigator's Annexe program.
| Product Type: | Antibody |
| Name: | Anti-Fascin 1 (55k-2) Monoclonal Antibody |
| Accession ID: | Q16658 |
| Host: | Mouse |
| Isotype: | IgG1 |
| Clonality: | Monoclonal |
| Clone Name: | 55k-2 |
| Specificity: | Mouse, rat and human Fascin 1 |
| Immunogen: | Native protein corresponding to full-length Human Fascin 1 (HeLa Cell origin) |
| Format: | Liquid |
| Purification Method: | Protein G purified |
| Buffer: | PBS, 0.05% (w/v) Sodium Azide |
| Tested Applications: | Western blotting and Immunofluorescence microscopy. |
| Concentration: | 1mg/mL |
| Amount: | 100uL |
| Storage: | Store at 4C |
| Shipped: | Cold packs |
- Yamakita Y, Matsumura F, Yamashiro S. Fascin1 is dispensable for mouse development but is favorable for neonatal survival. Cell Motil Cytoskeleton. 2009 Aug; 66(8):524-34.
- Yamakita Y, Matsumura F, Lipscomb MW, Chou PC, Werlen G, Burkhardt JK, Yamashiro S. Fascin1 promotes cell migration of Mature Dendritic Cells. J Immunol. 2011 Mar 1;186(5):2850-9. Epub 2011 Jan 24.
- Yamashiro-Matsumura S, Matsumura F. Intracellular localization of the 55-kD actin-bundling protein in cultured cells- spatial relationships with actin, alpha-actinin, tropomyosin, and fimbrin. J Cell Biol. 1986 Aug; 103(2):631-40.
- Yamashiro-Matsumura S, Matsumura F. Purification and characterization of an F-actin-bundling 55-kilodalton protein from HeLa cells. J Biol Chem. 1985 Apr 25;260(8):5087-97.
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