GFP-Rapabody Plasmid

GFP-Rapabody Plasmid for the expression of Rapamycin-controllable nanobody that specifically recognizes mCherry (chemical OFF switch).

Rapamycin is a compound belonging to the class of natural products (macrolides) that is used to coat coronary stents, prevent organ transplant rejection (especially in the case of kidney transplants) and treat a rare lung disease called lymphangioleiomyomatosis. It suppresses the activation of T cells and B cells by reducing their sensitivity to interleukin-2 (IL-2) through mTOR inhibition; acts as an immunosuppresant in humans. Furthemore, this compound is one of the most popular CID systems that takes advantage of its capability to dimerize FKBP12 and FRB domain of its mammalian target (mTOR). Rapabody(ies) refers to intrabodies (including both engineered nanobodies and monobodies) that can be controlled by rapamycine and its analogs.

From the laboratory of Yubin Zhou, MD, PhD, Texas A&M University.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
GFP-Rapabody Plasmid
250ng In stock
Regular Price:$80.00
On Sale:

Product Type: Plasmid
Gene/insert name: GFP-Rapabody
Accession ID: P42212
Organism: Synthetic
Antibiotic Resistance: Amp
Fusion Tag(s): GFP
Grow in E. coli at 37 C: Yes
Cloning Site 5': NcoI
Cloning Site 3': XhoI
Insert Size: 1704bp
Vector Backbone and Size: pTriEx, 4938bp
High or low copy: Low
Storage: -20C
Shipped: Room temperature

From the laboratory of Yubin Zhou, MD, PhD, Texas A&M University.

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