GFP-Rapabody Plasmid
GFP-Rapabody Plasmid for the expression of Rapamycin-controllable nanobody that specifically recognizes mCherry (chemical OFF switch).
Rapamycin is a compound belonging to the class of natural products (macrolides) that is used to coat coronary stents, prevent organ transplant rejection (especially in the case of kidney transplants) and treat a rare lung disease called lymphangioleiomyomatosis. It suppresses the activation of T cells and B cells by reducing their sensitivity to interleukin-2 (IL-2) through mTOR inhibition; acts as an immunosuppresant in humans. Furthemore, this compound is one of the most popular CID systems that takes advantage of its capability to dimerize FKBP12 and FRB domain of its mammalian target (mTOR). Rapabody(ies) refers to intrabodies (including both engineered nanobodies and monobodies) that can be controlled by rapamycine and its analogs.
From the laboratory of Yubin Zhou, MD, PhD, Texas A&M University.
GFP-Rapabody Plasmid for the expression of Rapamycin-controllable nanobody that specifically recognizes mCherry (chemical OFF switch).
Rapamycin is a compound belonging to the class of natural products (macrolides) that is used to coat coronary stents, prevent organ transplant rejection (especially in the case of kidney transplants) and treat a rare lung disease called lymphangioleiomyomatosis. It suppresses the activation of T cells and B cells by reducing their sensitivity to interleukin-2 (IL-2) through mTOR inhibition; acts as an immunosuppresant in humans. Furthemore, this compound is one of the most popular CID systems that takes advantage of its capability to dimerize FKBP12 and FRB domain of its mammalian target (mTOR). Rapabody(ies) refers to intrabodies (including both engineered nanobodies and monobodies) that can be controlled by rapamycine and its analogs.
From the laboratory of Yubin Zhou, MD, PhD, Texas A&M University.
| Product Type: | Plasmid |
| Gene/insert name: | GFP-Rapabody |
| Accession ID: | P42212 |
| Organism: | Synthetic |
| Antibiotic Resistance: | Amp |
| Fusion Tag(s): | GFP |
| Grow in E. coli at 37 C: | Yes |
| Cloning Site 5': | NcoI |
| Cloning Site 3': | XhoI |
| Insert Size: | 1704bp |
| Vector Backbone and Size: | pTriEx, 4938bp |
| High or low copy: | Low |
| Storage: | -20C |
| Shipped: | Room temperature |
If you publish research with this product, please let us know so we can cite your paper.
