Fluorescent Phenylalanine Analog (Phen-AA)

This novel fluorescent L-α-amino acid 4-phenanthracen-9-yl-L-phenylalanine (Phen-AA) emits greenish blue light in the visible region. The genetically encodable L-α-amino acid may find broad applications in research, biotechnology, and the pharmaceutical industry.


  • Excellent photostability with a 75% quantum yield
  • Its synthetic procedure (involving three simple steps and mild conditions) is resistant to racemization
  • Readily gets into human cells, being imaged clearly upon 405 nm laser excitation

Alpha-amino acids are the common natural forms of amino acids. They are simple molecules, containing a primary amine group (NH2) and a carboxylic group (COOH) separated by one carbon (alpha-carbon). Except for glycine, other natural amino acids adopt the L configuration. Phenylalanine is an essential α-amino acid. It is used in the manufacture of food and drink products and sold as a nutritional supplement for its reputed analgesic and antidepressant effects. The L-isomer is used to biochemically form proteins, coded for by DNA.

From the laboratory of Maolin Guo, PhD, University of Massachusetts Dartmouth.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
Fluorescent Phenylalanine Analog (Phen-AA)
2mg In stock
Regular Price:$218.00
On Sale:

Product Type: Small Molecule
Name: 4-phenanthracen-9-yl-L-phenylalanine (Phen-AA)
Chemical Formula: C23H19NO2
Molecular Weight: 341.14
Format: Off white powder
Purity: >95%
Solubility: Soluble in DMSO
Spectral Information: See reference: Chem. Commun., 2020,56, 12578-12581
Quantum Yield: 75%
Comments: Usually dissolve in DMSO first, then dilute it in a desired solvent or solvent mixture. The provider recommends 2mg per experiment.
Storage: -20C or -80C
Shipped: Dry ice

From the laboratory of Maolin Guo, PhD, University of Massachusetts Dartmouth.
  1. Gupta A , Garreffi BP , Guo M . Facile synthesis of a novel genetically encodable fluorescent Α-amino acid emitting greenish blue light. Chem Commun (Camb). 2020 Oct 25;56(83):12578-12581. doi: 10.1039/d0cc03643a. Epub 2020 Sep 18. PMID: 32944728; PMCID: PMC7577945.

If you publish research with this product, please let us know so we can cite your paper.