Human STAT3, rSTAT3-80
Recombinant human STAT3 protein, produced from E. coli.
The Signal transducer and activator of transcription 3 (STAT 3), functions as a cytoplasmic mediator of cytokine signaling and nuclear transcription factor. STAT3 is considered as one of the most crucial member of the STAT family. STAT3 activation occurs via the phosphorylation of tyrosine residue (Y705) by JAK (Janus Kinase) and serine (S727) by MAPK and non-receptor tyrosine kinases. In particular STAT 3 activity is detected in a wide variety of tumors, driving multiple pro-oncogenic functions.
Recombinant human STAT3 protein, produced from E. coli.
The Signal transducer and activator of transcription 3 (STAT 3), functions as a cytoplasmic mediator of cytokine signaling and nuclear transcription factor. STAT3 is considered as one of the most crucial member of the STAT family. STAT3 activation occurs via the phosphorylation of tyrosine residue (Y705) by JAK (Janus Kinase) and serine (S727) by MAPK and non-receptor tyrosine kinases. In particular STAT 3 activity is detected in a wide variety of tumors, driving multiple pro-oncogenic functions.
Specifications
| Product Type: | Protein |
| Name: | Human STAT3 |
| Alternative Name(s): | Signal transducer and activator of transcription 3, STAT3 |
| Accession ID: | P40763 |
| Source: | Human Ð expressed in E. coli |
| Molecular Weight: | 82.4 kDa |
| Amino Acid Sequence: | MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAASKE SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME IARIVARCLW EESRLLQTAA TAAQQGGQAN HPTAAVVTEK QQMLEQHLQD VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK SQGDMQDLNG NNQSVTRQKM QQLEQMLTAL DQMRRSIVSE LAGLLSAMEY VQKTLTDEELADWKRRQQIA CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR LLVKFPELNY QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGL KIDLETHSLP VVVISNICQM PNAWASILWY NMLTNNPKNV NFFTKPPIGT WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS GCQITWAKFC KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST KPPGTFLLRF SESSKEGGVT FTWVEKDISG KTQIQSVEPY TKQQLNNMSF AEIIMGYKIM DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG SAAPYLKTKF ICVTPT |
| Fusion Tag(s): | C-terminus 6 _ His tag |
| Format: | Lyophilized powder. Dilute to 1 mg/mL in PBS |
| Purity: | >98 %, purified by Ni NTA and determined by SDS-PAGE. |
| Buffer: | PBS |
| Tested Applications: | Drug discovery, research, cell proliferation assays |
| Comments: | Manufactured in an ISO 9001:20015 Certified Laboratory |
| Storage: | Store at -20 degree C, for extended storage |
| Shipped: | Cold packs |
Documentation
Provider
From the laboratory at GeNext Genomics Pvt Ltd.
References
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