Anti-Cochlin [9A10] Antibody

This rat IgG monoclonal antibody was raised against the N-terminal cochlin antigen corresponding to a.a. 7-227.

Cochlin is an extracellular matrix (ECM) protein highly abundant in the cochlea and vestibule of the inner ear, constituting the major non-collagen component of the ECM of the inner ear. The gene is expressed in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. Cochlin has been identified in the trabecular meshwork (TM) of glaucoma patients, but not in healthy controls. The TM is a filter like area of tissue in the eye; cochlin may have a role in cell adhesion, mechanosensation, and modulation of the TM filter. It is also expressed in follicular dendritic cells in spleen and lymph nodes. Here, cochlin is cleaved by aggrecanases and secreted into blood circulation during inflammation, contributing to the antibacterial innate immune response.

From the laboratory of Junying Yuan, PhD, Harvard University.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
Anti-Cochlin [9A10] Antibody
100ug 4-6 weeks
Regular Price:$345.00
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Product Type: Antibody
Accession ID: Q62507
Antigen: Cochlin
Isotype: IgG
Clonality: Monoclonal
Clone Name: 9A10
Immunogen: His-tagged Cochlin bacterial fusion protein (32kd of 2 LCC Domain and a small part of C' terminal); aa 7-227 of cochlin
Species Immunized: Rat
Purification Method: Protein G
Buffer: PBS, 0.05% (w/v) Sodium Azide
Storage: -20C
Shipped: Cold packs

From the laboratory of Junying Yuan, PhD, Harvard University.
  1. Py BF, Gonzalez SF, Long K, Kim MS, Kim YA, Zhu H, Yao J, Degauque N, Villet R, Ymele-Leki P, Gadjeva M, Pier GB, Carroll MC, Yuan J. Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity. Immunity. 2013 May 23;38(5):1063-72. doi: 10.1016/j.immuni.2013.01.015. Epub 2013 May 16. PMID: 23684986; PMCID: PMC3758559.

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