This rat IgG monoclonal antibody was raised against the N-terminal cochlin antigen corresponding to a.a. 7-227.
Cochlin is an extracellular matrix (ECM) protein highly abundant in the cochlea and vestibule of the inner ear, constituting the major non-collagen component of the ECM of the inner ear. The gene is expressed in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. Cochlin has been identified in the trabecular meshwork (TM) of glaucoma patients, but not in healthy controls. The TM is a filter like area of tissue in the eye; cochlin may have a role in cell adhesion, mechanosensation, and modulation of the TM filter. It is also expressed in follicular dendritic cells in spleen and lymph nodes. Here, cochlin is cleaved by aggrecanases and secreted into blood circulation during inflammation, contributing to the antibacterial innate immune response.
From the laboratory of Junying Yuan, PhD, Harvard University.
|Immunogen:||His-tagged Cochlin bacterial fusion protein (32kd of 2 LCC Domain and a small part of C' terminal); aa 7-227 of cochlin|
|Purification Method:||Protein G|
|Buffer:||PBS, 0.05% (w/v) Sodium Azide|
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