Mouse Neuroblastoma Cell Line (N2a[TRb1])

Neuro2A[TRβ1] mouse neuroblastoma cell line stably expressing human thyroid hormone receptor beta 1 (TRβ1).

From the laboratory of Robert J. Denver, PhD, University of Michigan.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
Mouse Neuroblastoma Cell Line (N2a[TRb1])
1 Vial In stock
Regular Price:$580.00
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Product Type: Cell Line
Name: Neuro2A[TRb1]
Cell Type: Neuron
Morphology: Neuronal
Organism: Mouse
Source: Mouse neuroblastoma
Biosafety Level: BSL1
Growth Conditions: DMEM/F12 supplemented with hygromycin B (500 ug/mL) and 10% fetal bovine serum stripped of thyroid hormone.
Subculturing: Can be passaged with trypsin per standard protocols
Cryopreservation: DMEM/F12 growth medium with 10% DMSO
Comments: Cell line first created by Lebel et al. (1994) exhibits robust gene expression responses to thyroid hormone (T3), and differentiates (extends neurites) after treatment with T3 for 3-5 days.
Storage: LN2
Shipped: Dry Ice

From the laboratory of Robert J. Denver, PhD, University of Michigan.
  1. Lebel JM, Dussault JH, Puymirat J. Overexpression of the beta 1 thyroid receptor induces differentiation in neuro-2a cells. Proc Natl Acad Sci U S A. 1994;91(7):2644-2648; Kyono, Y., Subramani, A., Ramadoss, P., Hollenberg, A.N., Bonett, R.M. and Denver, R.J. (2016) Liganded thyroid hormone receptors transactivate the DNA methyltransferase 3a gene in mouse neuronal cells. Endocrinology 157:3647-3657 doi: 10.1210/en.2015-1529 PMID:27387481

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