This mouse IgG1k monoclonal antibody was raised against glutathione-S-transferase fused to residues 1-121 of human SUN domain-containing protein 2 (SUN2) and recognizes human, mouse and rat SUN2.
SUN (Sad1, UNC-84) domain-containing proteins are type II membrane proteins that span the inner nuclear membrane. SUN proteins interact with lamins and other proteins in the nucleoplasm and with KASH (Klarsicht, ANC-1, and Syne homology) domain-containing proteins in the perinuclear space. Since the KASH proteins span the outer nuclear membrane and interact with components of the cytoskeleton, the SUN-KASH complex, also known as the LINC complex (LInker of the Nucleoskeleton and Cytoskeleton), provides a physical link between the nuclear interior and the cytoskeleton. The LINC complex is involved in diverse cellular functions including nuclear architecture, nuclear anchorage and migration, meiotic chromosome movement and cytoskeletal organization. Not surprisingly, aberrations in the LINC complex have been associated with number of human genetic diseases, including muscular dystrophy, cerebellar ataxia, hearing loss and infertility. In mammals the SUN protein family consists of at least 5 members. Sun1 and Sun2 share a high degree of homology and are ubiquitously expressed. Sun3-5 are more distantly related to Sun1-2 and have limited tissue expression.
From a laboratory at Agency for Science, Technology and Research (A*STAR).
|Accession ID:||25777, Q9UH99|
|Molecular Weight:||Human 80.3, mouse 81.6 kDa|
|Reactivity:||Human, mouse and rat|
|Immunogen:||Glutathione-S-transferase fused to residues 1-121 of human Sun2|
|Purification Method:||Protein G|
|Buffer:||PBS, 0.05% (w/v) Sodium Azide|
|Tested Applications:||Western Blot, Immunohistochemistry, Immunofluorescence/Immunocytochemistry|
If you publish research with this product, please let us know so we can cite your paper.