Anti-Sun2 [3.1E] Antibody

This mouse IgG1k monoclonal antibody was raised against glutathione-S-transferase fused to residues 1-121 of human SUN domain-containing protein 2 (SUN2) and recognizes human, mouse and rat SUN2.

Highlights:

  • Reacts with human, mouse and rat SUN2.
  • Suitable for Western Blot, Immunohistochemistry, Immunofluorsence and Immunocytochemistry applications

SUN (Sad1, UNC-84) domain-containing proteins are type II membrane proteins that span the inner nuclear membrane. SUN proteins interact with lamins and other proteins in the nucleoplasm and with KASH (Klarsicht, ANC-1, and Syne homology) domain-containing proteins in the perinuclear space. Since the KASH proteins span the outer nuclear membrane and interact with components of the cytoskeleton, the SUN-KASH complex, also known as the LINC complex (LInker of the Nucleoskeleton and Cytoskeleton), provides a physical link between the nuclear interior and the cytoskeleton. The LINC complex is involved in diverse cellular functions including nuclear architecture, nuclear anchorage and migration, meiotic chromosome movement and cytoskeletal organization. Not surprisingly, aberrations in the LINC complex have been associated with number of human genetic diseases, including muscular dystrophy, cerebellar ataxia, hearing loss and infertility. In mammals the SUN protein family consists of at least 5 members. Sun1 and Sun2 share a high degree of homology and are ubiquitously expressed. Sun3-5 are more distantly related to Sun1-2 and have limited tissue expression.

From a laboratory at Agency for Science, Technology and Research (A*STAR).

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
ESG033
Anti-Sun2 [3.1E] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
Specifications

Product Type: Antibody
Accession ID: 25777, Q9UH99
Antigen: Sun2
Molecular Weight: Human 80.3, mouse 81.6 kDa
Isotype: IgG1k
Clone Name: 3.1E
Reactivity: Human, mouse and rat
Immunogen: Glutathione-S-transferase fused to residues 1-121 of human Sun2
Species Immunized: Mouse
Purification Method: Protein G
Buffer: PBS, 0.05% (w/v) Sodium Azide
Tested Applications: Western Blot, Immunohistochemistry, Immunofluorescence/Immunocytochemistry
Storage: -20C
Shipped: Cold Packs

References
  1. Crisp, M., Q. Liu, K. Roux, J.B. Rattner, C. Shanahan, B. Burke, P.D. Stahl, and D. Hodzic. 2006. Coupling of the nucleus and cytoplasm: role of the LINC complex. J Cell Biol. 172:41-53.
  2. Rothballer, A., T.U Schwartz, U. Kutay U. 2013. LINCing complex functions at the nuclear envelope. Nucleus. 4(1):29-36.
  3. Horn, H.F. 2014. LINC complex proteins in development and disease. Current topics in developmental biology. 109:287-321.
  4. Göb, E., E. Meyer-Natus, R. Benavente, M. Alsheimer. 2011. Expression of individual mammalian Sun1 isoforms depends on the cell type. Commun Integr Biol. (4):440-2.
  5. Nishioka, Y., H. Imaizumi, J. Imada, J. Katahira, N. Matsuura, M. Hieda. 2016. SUN1 splice variants, SUN1_888, SUN1_785, and predominant SUN1_916, variably function in directional cell migration. Nucleus. 7(6): 572-584.

If you publish research with this product, please let us know so we can cite your paper.

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