Anti-Influenza A H3N2v, A/Minnesota/11/2010, Neuraminidase [B10] Antibody

This mouse monoclonal antibody (IgG2a) was raised against the NA of the swine-origin variant influenza A H3N2 virus A/Minnesota/11/2010.

Highlights:

  • Reacts with the NA of the swine-origin H3N2 variant viruses that have infected humans and human seasonal H3N2 viruses circulated before the 2014-2015 influenza season, when an N-linked glycosylation site was introduced to residue 245 of NA (N2 subtype)
  • Binds to an epitope consist of 14 amino acids within and around the active site
  • Suitable for ELISA, immunofluorescence assay and NA inhibition assay

Influenza A H3N2 virus has long been circulating in humans together with H1N1 and influenza B viruses, resulting in annual influenza epidemics. While hemagglutinin (HA) on the surface of influenza virus is responsible for viral binding to and entry into host cells, neuraminidase (NA) as the second most abundant surface glycoprotein facilitates the release of the progeny virions for infecting more cells. NA is also the major target of FDA-approved antivirals that are used in treating influenza.

From the laboratory of Hongquan Wan, DVM, PhD, Food and Drug Administration.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
EFD016
Anti-Influenza A H3N2v, A/Minnesota/11/2010, Neuraminidase [B10] Antibody
100ug 4-6 weeks
Regular Price:$328.00
On Sale:
Specifications

Product Type: Antibody
Accession ID: P0DOF9
Isotype: IgG2a
Clonality: Monoclonal
Clone Name: B10
Reactivity: Reacts with the NA of the swine-origin H3N2 variant viruses that have infected humans and human seasonal H3N2 viruses circulated before the 2014-2015 influenza season, when an N-linked glycosylation site was introduced to residue 245 of NA (N2 subtype)
Immunogen: Purified MN/10 virus
Species Immunized: Mouse
Epitope: 14 amino acids overlapping with the NA (N2 subtype) active site
Purification Method: Protein G
Buffer: PBS, 0.05% (w/v) Sodium Azide
Tested Applications: ELISA, ELLA, MUNANA
Storage: -20C
Shipped: Cold Packs

Provider
From the laboratory of Hongquan Wan, DVM, PhD, Food and Drug Administration.
References
  1. Hongquan W. Gao J. Yang H. Yang S. Harvey S. Chen Y. Zheng N. Chang J. Carney PJ. Li X. Plant E. Jiang Lianlian. Couzens L. Wang C. Strohmeier S, Wu WW. Shen RF. Krammer F. Cipollo JF. Wilso PC. Stevens J. Wan XF. Eichelberger MC. Ye Z. The neuraminidase of A(H3N2) influenza viruses circulating since 2016 is antigenically distinct from the A/Hong Kong/4801/2014 vaccine strain. Nat Microbiol. 2019 December. 4(12);2216-2225.

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