Anti-Arginine-Gingipain B (RgpB) [18E6] Antibody

This mouse IgG1 monoclonal anitbody was raised against protein and recognzies Porphyromonas gingivalis arginine-gingipain B (RgpB).

Highlights:

  • Reacts with p. gingivalis RgpB
  • Suitable for Immunoprecipitation and Immunofluorescence applications

Porphyromonas gingivalis is an oral pathogen that can induce periodontal disease. RgbP has also been detected in the brains of Alzheimer's disease patients with levels correlating with disease markers.

 

From a laboratory at University of Georgia..

Catalog Number Product Size AVAILABILITY Price Qty
EGA266
Anti-Arginine-Gingipain B (RgpB) [18E6] Antibody
100ug 3-5 weeks
Regular Price:$299.00
Specifications

Product Type: Antibody
Accession ID: CPG2_PORGI
Antigen: Arginine-gingipain B
Molecular Weight: 485 kDa
Isotype: IgG1
Clonality: Monclonal
Clone Name: 18 E6
Immunogen: Protein
Species Immunized: Mouse
Purification Method: Protein G
Buffer: 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide
Tested Applications: IP, IF
Storage: -20C
Shipped: Cold Packs

Provider
From a laboratory at University of Georgia.
References
  1. Nguyen KA, Travis J, Potempa J. Does the importance of the C-terminal residues in the maturation of RgpB from Porphyromonas gingivalis reveal a novel mechanism for protein export in a subgroup of Gram-Negative bacteria?. J Bacteriol. 2007;189(3):833-843. doi:10.1128/JB.01530-06.
  2. Dominy SS, Lynch C, Ermini F, et al. Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Sci Adv. 2019;5(1):eaau3333. Published 2019 Jan 23.
  3. Pomowski A, Usón I, Nowakowska Z, et al. Structural insights unravel the zymogenic mechanism of the virulence factor gingipain K from Porphyromonas gingivalis, a causative agent of gum disease from the human oral microbiome. J Biol Chem. 2017;292(14):5724-5735.
  4. Potempa J, Pike R, Travis J. The multiple forms of trypsin-like activity present in various strains of Porphyromonas gingivalis are due to the presence of either Arg-gingipain or Lys-gingipain. Infect Immun. 1995;63(4):1176-1182.

If you publish research with this product, please let us know so we can cite your paper.

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