Anti-Caspase 8 [1H10] Antibody
This IgG2a rat monoclonal antibody was generated against a full length bacterial fusion protein and recognizes human caspase 8.
Caspase 8, an enzyme encoded by the CASP8 gene, is a member of the cysteine-aspartic acid protease family. Sequential activation of the caspases is critical for cell apoptosis. Caspase 8 acts upon caspases 3 and 7 following death receptor stimulation.
From a laboratory at Harvard University.
Part of The Investigator's Annexe program.
This IgG2a rat monoclonal antibody was generated against a full length bacterial fusion protein and recognizes human caspase 8.
Caspase 8, an enzyme encoded by the CASP8 gene, is a member of the cysteine-aspartic acid protease family. Sequential activation of the caspases is critical for cell apoptosis. Caspase 8 acts upon caspases 3 and 7 following death receptor stimulation.
From a laboratory at Harvard University.
Part of The Investigator's Annexe program.
Specifications
| Product Type: | Antibody |
| Name: | Anti-Caspase 8 (1H10) |
| Accession ID: | Q14790 |
| Host: | Rat |
| Isotype: | IgG2a |
| Clonality: | Monoclonal |
| Clone Name: | 1H10 |
| Specificity: | Caspase 8 (human) |
| Immunogen: | Bacterial fusion protein(full length) |
| Format: | Liquid |
| Purification Method: | Protein G affinity purified |
| Tested Applications: | WB, ELISA, IHC |
| Concentration: | 1mg/mL |
| Amount: | 100uL |
| Storage: | Store at 4C |
| Shipped: | Cold packs |
Provider
From a laboratory at Harvard University.
References
- Toshiyuki Nakagawa et al. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-ß. Nature, Vol 403, 2 January 2000
- Ivelisse Sanchez et al. Caspase-8 Is Required for Cell Death Incuced by Expanded Polyglutamine Repeats. Neuron, Vol. 22, 623-633, March 1999
- Honglin Li et al. Cleavage of Bid by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis. Cell, Vol. 94, 491-501, August 21, 1998
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