Anti-Caspase 12 [14F7] Antibody

This IgG2a rat monoclonal antibody was generated against the bacterial fusion protein p30 and recognizes mouse caspase 12.

Caspase 12, an enzyme encoded by the CASP12 gene, is a member of the cysteine-aspartic acid protease family. Sequential activation of caspases is critical for cell apoptosis. Once a stimulus is received by the cell, discrete apoptotic pathways are potentiated by subsets of the caspases that can then activate additional intracellular effectors. Caspase 12 is involved in apoptosis induced by ER stress.

From a laboratory at Harvard University.

The Investigator's Annexe Part of The Investigator's Annexe program.

Catalog Number Product Size AVAILABILITY Price Qty
EF0004
Anti-Caspase 12 [14F7] Antibody
100ug 2-3 weeks
Regular Price:$254.00
Specifications

Product Type: Antibody
Name: Anti-Caspase 12 (14F7)
Host: Rat
Isotype: IgG2a
Clonality: Monoclonal
Clone Name: 14F7
Specificity: Caspase 12 (mouse)
Immunogen: Bacterial fusion protein (p30)
Format: Liquid
Purity: Protein G affinity purified
Tested Applications: WB, ELISA, IHC, IP
Concentration: 1mg/mL
Amount: 100uL
Storage: Store at 4C
Shipped: Cold packs

Provider
From a laboratory at Harvard University.
References
  1. Juying Li. Et al. Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization. Nature Cell Biology, Vol 9, Number3, March 2007
  2. Toshiyuki Nakagawa et al. Cross-talk between Two Cysteine Protease Families: Activation of Caspase-12 by Calpain in Apoptosis. JCB, Vol 150, Number 4, August 21, 2000
  3. Toshiyuki Nakagawa et al. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-ß. Nature, Vol 403, 2 January 2000

If you publish research with this product, please let us know so we can cite your paper.

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