Mannan-Binding Lectin Serine Protease 2 (MASP-2)
Mannan-Binding Lectin Serine Protease 2 (MAPS-2) expressed in E. Coli.
MASP-2 is involved in the complement system. MASP-2 is very similar to the C1s molecule, of the classical complement pathway, and they are thought to have a common evolutionary ancestor. When the carbohydrate-recognizing heads of MBL bind to specifically arranged mannose residues on the surface of a pathogen, MASP-2 is activated to cleave complement components C4 and C2 into C4a, C4b, C2a, and C2b.
From the laboratory of Lakshmi C. Wijeyewickrema, PhD, La Trobe University.
Mannan-Binding Lectin Serine Protease 2 (MAPS-2) expressed in E. Coli.
MASP-2 is involved in the complement system. MASP-2 is very similar to the C1s molecule, of the classical complement pathway, and they are thought to have a common evolutionary ancestor. When the carbohydrate-recognizing heads of MBL bind to specifically arranged mannose residues on the surface of a pathogen, MASP-2 is activated to cleave complement components C4 and C2 into C4a, C4b, C2a, and C2b.
From the laboratory of Lakshmi C. Wijeyewickrema, PhD, La Trobe University.
Specifications
| Product Type: | Protein |
| Name: | MASP2CCP12SP |
| Accession ID: | O00187 |
| Source: | Escherichia coli |
| Molecular Weight: | 43744.6 (Predicted); around 16kDa and 26kDa on SDS-PAGE under reducing condition |
| Amino Acid Sequence: | T287-F686 |
| Purity: | >95%, by SDS-PAGE under reducing conditions and visualized by Coomassie Blue Stain |
| Buffer: | 20 mM Tris, 150mM Nacl, pH7.5 |
| Storage: | -80C |
| Shipped: | Dry Ice |
Documentation
Data
SDS-PAGE
Provider
From the laboratory of Lakshmi C. Wijeyewickrema, PhD, La Trobe University.
References
- Duncan RC, Mohlin F, Taleski D, Coetzer TH, Huntington JA, Payne RJ, Blom AM, Pike RN, Wijeyewickrema LC. Identification of a catalytic exosite for complement component C4 on the serine protease domain of C1s. J Immunol. 2012 Sep 1;189(5):2365-73.
- Duncan RC, Bergström F, Coetzer TH, Blom AM, Wijeyewickrema LC, Pike RN. Multiple domains of MASP-2, an initiating complement protease, are required for interaction with its substrate C4. Mol Immunol. 2012;49(4):593-600. doi:10.1016/j.molimm.2011.10.006
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