Mannan-Binding Lectin Serine Protease 1 (MAPS-1) expressed in E. Coli.
MASP-1 is a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. MASP-1 is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. MASP-1 is also able to cleave fibrinogen and factor XIII and may be involved in coagulation.
From the laboratory of Lakshmi C. Wijeyewickrema, PhD, La Trobe University.
|Molecular Weight:||45072.58 (Predicted), around 16kDa and 28kDa on SDS-PAGE under reducing condition|
|Amino Acid Sequence:||G298-N699|
|Purity:||>95%, by SDS-PAGE under reducing conditions and visualized by Coomassie Blue Stain|
|Buffer:||20 mM Tris, 150mM Nacl, pH7.5|
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