Anti-Diisocyanate (dNCO) [15D4] Antibody

This mouse IgM monoclonal antibody was raised against 4,4'-methylene diphenyl diisocyanate (MDI) and recognizes MDI.


  • Boradly reacts with dNCO adducted human serum albumin (HSA)
  • Suitable for ELISA; Immunoassay applications

Diisocyanates (dNCOs) are chemicals used in the production of polyurethane polymers. 4,4'-methylene diphenyl diisocyanate (MDI) is one of the most commonly used dNCO in industrial applications. Diisocyanates are potent allergens and are the most commonly reported cause of occupational asthma (OA) in North America. Diisocyanates form adducts with blood and plasma which can be used as detectable biomarkers for assessing dNCO occupational exposure.

From the laboratory of Centers for Disease Control and Prevention.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
Anti-Diisocyanate (dNCO) [15D4] Antibody
5mL 4-6 weeks
Regular Price:$290.00
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Product Type: Antibody
Antigen: Diisocyanate (dNCO)
Isotype: IgM
Clonality: Monoclonal
Clone Name: 15D4
Immunogen: 4,4'-methylene diphenyl diisocyanate (MDI)
Species Immunized: Mouse
Buffer: Cell Culture Supernatant
Tested Applications: ELISA; Immunoassay (2ug/mL)
Storage: -80C
Shipped: Cold Packs

  1. Lemons AR, Siegel PD, Mhike M, Law BF, Hettick JM, Bledsoe TA, Nayak AP, Beezhold DH, Green BJ. A murine monoclonal antibody with broad specificity for occupationally relevant diisocyanates. J Occup Environ Hyg. 2014;11(2):101-10.
  2. Mhike M, Chipinda I, Hettick JM, Simoyi RH, Lemons A, Green BJ, Siegel PD. Characterization of methylene diphenyl diisocyanate-haptenated human serum albumin and hemoglobin. Anal Biochem. 2013 Sep 15;440(2):197-204.
  3. Luna LG, Green BJ, Zhang F, Arnold SM, Siegel PD, Bartels MJ. Quantitation of 4,4'-methylene diphenyl diisocyanate human serum albumin adducts. Toxicol Rep. 2014;1:743-751. PubMed PMID: 26877973; PubMed Central PMCID: PMC4748379.

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