Lysine funtionalized nanodiamond based DNA delivery reagent that can deliver genetic materials to mammalian cells and can be exploited for use in gene therapy.
Nanodiamond (NDs) based gene delivery systems offer unique structural, chemical and biological properties that are safer compared to currently available viral andnon-viral gene delivery systems. NDs have been used successfully to deliver chemotherapeutic agents to cancer cells, plasmid DNA and siRNA into cell lines. Despite the use of NDs as vectors for delivering therapeutic agents and genetic material, it is a challenge to obtain nanosized particles in laboratory and industry scale as NDs tend to aggregate into micron-sized aggregates that are toxic to biological systems. The technology overcomes this limitation as the lysine functionalized nanodiamonds are stable in aqueous medium and have smaller hydrodynamic radii compared to the currently available polymer based functionalized nanodiamonds.
From the laboratory of Ildiko Badea, PhD, University of Saskatchewan.
|Product Type:||Small Molecule|
|Internal Contents:||Sp2 Carbon|
|Comments:||Refractive index = 2.4|
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