This mouse monoclonal antibody was generated against a cysteinylated two-sugar antiproliferative factor (APF) derivative (Gal-GalNAc-TVPAAVVVAC) and recognizes two-sugar APF derivitives.
Antiproliferative factor (APF) is a low molecular weight, heat stable sialoglycopeptide that containsthe transmembrane segment of Frizzled 8. It is made and secreted by bladder epithelial cells of patients with acondition known as interstitial cystitis (IC) which causes chronic pain due to ulcers, hemorrhaging, and thinning of the bladder epithelium. APF contributes to the pathology of IC by inhibiting bladder cell proliferation, and was also shown to regulate proliferation of bladder carcinoma cells. Recently, CKAP4/p63 was identified as a receptor for APF, but how its activity is mediated remains unknown.
From the laboratory of Susan K. Keay, MD, PhD, Department of Veterans Affairs.
|KLH-conjugated glycosylated peptide
|Method Used to Determine Concentration:
|PBS, pH 7.4
|APF bioassay/dot blot
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