Anti-Influenza A H1N1, Neuraminidase (NA) [CD6] Antibody

This mouse monoclonal antibody (IgG2a) was raised against the NA of the 2009 pandemic H1N1 virus A/California/07/2009.

Highlights:

  • Reacts with the NA of the 2009 pandemic influenza A H1N1 viruses currently circulating in humans and animals
  • Recognizes a highly conserved N1 epitope consists of 30 amino acids distributing on two neighboring NA monomers
  • Suitable for ELISA, immunofluorescence assay and NA inhibition assay
  • Can be used in NA potency assessment of influenza vaccines

Influenza A H1N1 virus has long been circulating in humans together with H3N2 and influenza B viruses, resulting in annual influenza epidemics. H1N1 virus contains two major surface glycoproteins haemagglutinin (HA) and neuraminidase (NA). HA is responsible for binding sialic acid receptors on host cells and the subsequent endocytosis and fusion, while NA facilitates the release of progeny virions from infected cells and thus plays an important role in the spread of influenza viruses. NA-specific immunity provides protection influenza, and NA is the major target of FDA-approved antivirals that are used in treating influenza.

From the laboratory of Hongquan Wan, DVM, PhD, Food and Drug Administration.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
EFD001
Anti-Influenza A H1N1, Neuraminidase (NA) [CD6] Antibody
100ug In stock
Regular Price:$328.00
On Sale:
Specifications

Product Type: Antibody
Accession ID: P03470
Isotype: IgG2a
Clonality: Monoclonal
Clone Name: CD6
Reactivity: Reacts with the NA of the 2009 pandemic H1N1 influenza viruses
Immunogen: Influenza A H1N1 virus A/California/07/2009
Species Immunized: Mouse
Epitope: A conserved N1 epitope consists of 30 amino acids distributing on two neighboring NA monomers.
Purification Method: Protein G
Buffer: 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide
Storage: -20C
Shipped: Cold Packs

Provider
From the laboratory of Hongquan Wan, DVM, PhD, Food and Drug Administration.

References
  1. Wan H, Yang H, Shore DA, Garten RJ, Couzens L, Gao J, Jiang L, Carney PJ,Villanueva J, Stevens J, Eichelberger MC. Structural characterization of aprotective epitope spanning A(H1N1)pdm09 influenza virus neuraminidase monomers. Nat Commun. 2015 Feb 10;6:6114.
  2. Jiang L, Fantoni G, Couzens L, Gao J, Plant E, Ye Z, Eichelberger M, Wan H. Comparative Efficacy of Monoclonal Antibodies That Bind to Different Epitopes of the 2009 Pandemic H1N1 Influenza Virus Neuraminidase. Journal of Virology, 2016, 90(1): 117-128.

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