This mouse monoclonal antibody (IgG2a) was raised against the NA of the 2009 pandemic H1N1 virus A/California/07/2009.
Influenza A H1N1 virus has long been circulating in humans together with H3N2 and influenza B viruses, resulting in annual influenza epidemics. H1N1 virus contains two major surface glycoproteins haemagglutinin (HA) and neuraminidase (NA). HA is responsible for binding sialic acid receptors on host cells and the subsequent endocytosis and fusion, while NA facilitates the release of progeny virions from infected cells and thus plays an important role in the spread of influenza viruses. NA-specific immunity provides protection influenza, and NA is the major target of FDA-approved antivirals that are used in treating influenza.
From the laboratory of Hongquan Wan, DVM, PhD, Food and Drug Administration.
|Antigen:||Influenza A H1N1, Neuraminidase (NA)|
|Immunogen:||Influenza A H1N1 virus A/California/07/2009|
|Epitope:||A conserved N1 epitope consists of 30 amino acids distributing on two neighboring NA monomers.|
|Purification Method:||Protein G|
|Buffer:||0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide|
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